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Substance Name: Alrestatin [INN]
RN: 51411-04-2
UNII: 515DHK15LG
InChIKey: GCUCIFQCGJIRNT-UHFFFAOYSA-N

Note

  • Aldose reductase inhibitor.

Molecular Formula

  • C14-H9-N-O4

Molecular Weight

  • 255.2281
 

Classification Codes

  • Autonomic Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Parasympatholytics
  • Peripheral Nervous System Agents
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Names and Synonyms

Results Name

  • Alrestatin [INN]

Name of Substance

  • Alrestatin
  • Alrestatin [INN]

Synonyms

  • 1,3-Dioxo-1H-benz(de)isoquinoline-2(3H)-acetic acid
  • 2,3-Dihydro-1,3-dioxo-1H-benz(de)isochiolin-2-essigsaeure
  • 4-21-00-05562 (Beilstein Handbook Reference)
  • Alrestatin
  • Alrestatine
  • Alrestatine [INN-French]
  • Alrestatino
  • Alrestatino [INN-Spanish]
  • Alrestatinum
  • Alrestatinum [INN-Latin]
  • AY 22284
  • BRN 0244370
  • NSC 299132
  • UNII-515DHK15LG

Systematic Names

  • 1,3-Dioxo-1H-benz(de)isoquinoline-2(3H)-acetate
  • 1H-Benz(de)isoquinoline-2(3H)-acetic acid, 1,3-dioxo-

Registry Numbers

CAS Registry Number

  • 51411-04-2

FDA UNII

  • 515DHK15LG

System Generated Number

  • 0051411042

Structure Descriptors

InChI

1S/C14H9NO4/c16-11(17)7-15-13(18)9-5-1-3-8-4-2-6-10(12(8)9)14(15)19/h1-6H,7H2,(H,16,17)

InChIKey

GCUCIFQCGJIRNT-UHFFFAOYSA-N

Smiles

c1cc2cccc3c2c(c1)C(=O)N(C3=O)CC(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 intraperitoneal 1380mg/kg (1380mg/kg)   United States Patent Document. Vol. #4118495,
rat LD50 intravenous 1220mg/kg (1220mg/kg)   United States Patent Document. Vol. #4118495,
rat LD50 oral > 2500mg/kg (2500mg/kg)   United States Patent Document. Vol. #4405625,