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Substance Name: Difenpiramide
RN: 51484-40-3
UNII: Q6U5F6E1QL
InChIKey: PWHROYKAGRUWDQ-UHFFFAOYSA-N

Note

  • Non-steroidal anti-inflammatory agent.

Molecular Formula

  • C19-H16-N2-O

Molecular Weight

  • 288.348
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Drug / Therapeutic Agent
  • Peripheral Nervous System Agents
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Difenpiramide

Synonyms

  • 2-Biphenylyl-N-pyridylacetamide
  • 5-22-08-00334 (Beilstein Handbook Reference)
  • BRN 0483768
  • Difenpiramide
  • Diphenpyramide
  • EINECS 257-235-9
  • N-2-Pyridinyl-(1,1'-biphenyl)-4-acetamide
  • NSC 305337
  • Pyridyl-biphenylyl-acetamide
  • UNII-Q6U5F6E1QL
  • Z-876

Systematic Names

  • (1,1'-Biphenyl)-4-acetamide, N-2-pyridinyl- (9CI)
  • Acetamide, 2-biphenylyl-N-pyridyl-
  • N-Pyridin-2-yl(1,1'-biphenyl)-4-acetamide

Registry Numbers

CAS Registry Number

  • 51484-40-3

FDA UNII

  • Q6U5F6E1QL

System Generated Number

  • 0051484403

Structure Descriptors

InChI

1S/C19H16N2O/c22-19(21-18-8-4-5-13-20-18)14-15-9-11-17(12-10-15)16-6-2-1-3-7-16/h1-13H,14H2,(H,20,21,22)

InChIKey

PWHROYKAGRUWDQ-UHFFFAOYSA-N

Smiles

C(Nc1ncccc1)(=O)Cc1ccc(cc1)c1ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 1gm/kg (1000mg/kg) BEHAVIORAL: ANALGESIA Bollettino Chimico Farmaceutico. Vol. 118, Pg. 729, 1979.
mouse LD50 intraperitoneal 1471mg/kg (1471mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 2086, 1977.
mouse LD50 oral 2590mg/kg (2590mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 2086, 1977.
rabbit LD50 oral 4gm/kg (4000mg/kg)   Bollettino Chimico Farmaceutico. Vol. 118, Pg. 729, 1979.
rabbit LD50 oral 4gm/kg (4000mg/kg) BEHAVIORAL: ANALGESIA Bollettino Chimico Farmaceutico. Vol. 118, Pg. 729, 1979.
rat LD50 intraperitoneal 1396mg/kg (1396mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 2086, 1977.
rat LD50 oral 1857mg/kg (1857mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 2086, 1977.