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Substance Name: Cycloguanil
RN: 516-21-2
UNII: 26RM326WVN
InChIKey: QMNFFXRFOJIOKZ-UHFFFAOYSA-N

Note

  • The active metabolite of proguanil; antifolate drug.

Molecular Formula

  • C11-H14-Cl-N5

Molecular Weight

  • 251.7196
 

Classification Codes

  • Anti-Infective Agents
  • Antimalarials
  • Antiparasitic Agents
  • Antiprotozoal Agents
  • Enzyme Inhibitors
  • Folic Acid Antagonists
  • Mutation Data
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Cycloguanil

Synonyms

  • 1-(p-Chlorophenyl)-4,6-diamino-2,2-dimethyl-1,2-dihydro-s-triazine
  • 1-p-Chlorophenyl-1,2-dihydro-2,2-dimethyl-4,6-diamino-s-triazine
  • 4-26-00-01176 (Beilstein Handbook Reference)
  • 4-Amino-6-p-chloroanilino-1,2-dwuhydro-2,2-dwumethylo-1,3,5-trojazyna
  • 4-Amino-6-p-chloroanilino-1,2-dwuhydro-2,2-dwumethylo-1,3,5-trojazyna [Polish]
  • BN-24-10
  • BN2410
  • BRN 0229760
  • CGT
  • Chlorguanide triazine
  • Cycloguanil
  • Cycloguanilum
  • Cycloguanyl
  • UNII-26RM326WVN
  • WR 5473

Systematic Names

  • 1,3,5-Triazine-2,4-diamine, 1,6-dihydro-1-(4-chlorophenyl)-6,6-dimethyl- (9CI)
  • s-Triazine, 1,2-dihydro-1-(p-chlorophenyl)-4,6-diamino-2,2-dimethyl-

Registry Numbers

CAS Registry Number

  • 516-21-2

FDA UNII

  • 26RM326WVN

Related Registry Number

  • 152-53-4 (hydrochloride)

System Generated Number

  • 0000516212

Structure Descriptors

InChI

1S/C11H14ClN5/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8/h3-6H,1-2H3,(H4,13,14,15,16)

InChIKey

QMNFFXRFOJIOKZ-UHFFFAOYSA-N

Smiles

CC1(C)N=C(N)N=C(N)N1c2ccc(Cl)cc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 intraperitoneal 98mg/kg (98mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Dissertationes Pharmaceuticae. Vol. 10, Pg. 81, 1958.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 146 deg C   EXP
log P (octanol-water) 0.960 (none)   EST
Atmospheric OH Rate Constant 8.51E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.