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Substance Name: Fluorescein sodium [USP:BAN:JAN]
RN: 518-47-8
UNII: 93X55PE38X
InChIKey: NJDNXYGOVLYJHP-UHFFFAOYSA-L

Note

  • A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal injuries and corneal trauma. It has been approved by FDA for use in externally applied drugs and cosmetics. (From Merck Index, 12th ed; American Medical Association Drug Evaluations; 1995, p2275)

Molecular Formulas

  • C20-H10-Na2-O5
  • C20-H10-O5.2Na
  • C20-H12-O5.2Na

Molecular Weight

  • 376.274
 

Classification Codes

  • Diagnostic Aid (Corneal Trauma Indicator)
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Tumor Data
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Names and Synonyms

Name of Substance

  • 3',6'-Dihydroxyspiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, disodium salt
  • CI 45350
  • CI 45350 (Na salt)
  • D & C Yellow no. 8
  • Fluorescein disodium salt
  • Fluorescein sodium [USP:BAN:JAN]
  • Sodium fluorescein
  • Uranine

Synonyms

  • 11824 Yellow
  • 12417 Yellow
  • 9-o-Carboxyphenyl-6-hydroxy-3-isoxanthone, disodium salt
  • Acid Yellow 73
  • Aizen uranine
  • Ak-Fluor
  • Basacid Yellow 226
  • C.I. 45350
  • C.I. Acid Yellow 73
  • Calcocid uranine B4315
  • CCRIS 6239
  • Certiqual fluoresceine
  • D&C Yellow No. 8
  • Disodium 6-hydroxy-3-oxo-9-xanthene-o-benzoate
  • EINECS 208-253-0
  • Fluor-I-Strip
  • Fluor-I-strip A.T.
  • Fluorescein disodium salt
  • Fluorescein LT
  • Fluorescein sodium
  • Fluorescein sodium B.P
  • Fluorescein, disodium salt
  • Fluorescein, soluble
  • Fluorescite
  • Flurenate
  • Ful-Glo
  • Funduscein
  • Funduscein-25
  • Furanium
  • Hidacid uranine
  • HSDB 8007
  • Japan Yellow 202(1)
  • NCI-C54706
  • Obiturine
  • Resorcinol phthalein sodium
  • Sodium fluorescein
  • Sodium fluoresceinate
  • Sodium salt of hydroxy-o-carboxy-phenyl-fluorone
  • Soluble fluorescein
  • Soluble fluoresceine
  • Soluble Fluoresceine BPS
  • Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-, disodium salt
  • Spiro(isobenzofuran-1(3H),9'-(9H)xanthene)-3-one, 3'6'-dihydroxy, disodium salt
  • UNII-93X55PE38X
  • Uranin
  • Uranin A
  • Uranin S
  • Uranine
  • Uranine A
  • Uranine A Extra
  • Uranine O
  • Uranine SS
  • Uranine WSS
  • Uranine Yellow

Systematic Names

  • C.I. Acid Yellow 73
  • Disodium 2-(3-oxo-6-oxidoxanthen-9-yl)benzoate
  • Fluorescein, disodium salt
  • Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-, disodium salt
  • Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-, sodium salt (1:2)

Superlist Name

  • C.I. Acid Yellow 73

Mixture Name

  • Fluress

Registry Numbers

CAS Registry Number

  • 518-47-8

FDA UNII

  • 93X55PE38X

Other Registry Numbers

  • 121511-05-5
  • 1279055-25-2
  • 135354-40-4
  • 208117-76-4
  • 31949-37-8
  • 3266-99-7
  • 34517-88-9
  • 41935-48-2
  • 574737-69-2
  • 893427-14-0

Related Registry Number

  • 2321-07-5 (Parent)

System Generated Number

  • 0000518478

Molecular Formulas

Molecular Formulas

  • C20-H10-Na2-O5
  • C20-H10-O5.2Na
  • C20-H12-O5.2Na

Molecular Formula Fragments

  • C20-H10-O5
  • C20-H12-O5
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C20H12O5.2Na/c21-11-5-7-15-17(9-11)25-18-10-12(22)6-8-16(18)19(15)13-3-1-2-4-14(13)20(23)24;;/h1-10,21H,(H,23,24);;/q;2*+1/p-2

InChIKey

NJDNXYGOVLYJHP-UHFFFAOYSA-L

Smiles

c1(c2c(oc3c1ccc(c3)[O-])cc(=O)cc2)c1c(cccc1)C(=O)[O-].[Na+].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 1gm/kg (1000mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS Toxicology and Applied Pharmacology. Vol. 29, Pg. 97, 1974.
guinea pig LDLo intraperitoneal 1gm/kg (1000mg/kg)   Chemical Warfare Laboratories Technical Memorandum. Vol. #47-6, Pg. 1959,
man TDLo intravenous 7142ug/kg (7.142mg/kg) SENSE ORGANS AND SPECIAL SENSES: HEMORRHAGE: EYE

GASTROINTESTINAL: NAUSEA OR VOMITING
American Journal of Ophthalmology. Vol. 103, Pg. 111, 1987.
man TDLo intravenous 14mg/kg/10M-I (14mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) Anesthesia and Analgesia Vol. 66, Pg. 283, 1987.
mouse LD50 intravenous 1gm/kg (1000mg/kg)   Toxicology and Applied Pharmacology. Vol. 29, Pg. 97, 1974.
mouse LD50 oral 4738mg/kg (4738mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Periodontology. Vol. 48, Pg. 228, 1977.
rat LD50 intravenous 1gm/kg (1000mg/kg) BLOOD: OTHER CHANGES Toxicology and Applied Pharmacology. Vol. 29, Pg. 97, 1974.
rat LD50 oral 6721mg/kg (6721mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Periodontology. Vol. 48, Pg. 228, 1977.