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Substance Name: Corydaline
RN: 518-69-4
UNII: 08N392L8VX
InChIKey: VRSRXLJTYQVOHC-YEJXKQKISA-N

Note

  • An acetylcholinesterase inhibitor isolated from Corydalis yanhusuo.

Classification Codes

  • Enzyme Inhibitors
  • Natural Product

Molecular Formula

  • C22-H27-N-O4

Molecular Weight

  • 369.458
 
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Names and Synonyms

Name of Substance

  • Corydaline

Synonyms

  • (+)-Corydaline
  • 5-21-06-00173 (Beilstein Handbook Reference)
  • 6H-Dibenzo(a,g)quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-13-methyl-, (13S-E)-
  • Berbine, 2,3,9,10-tetramethoxy-13-methyl-
  • BRN 0096972
  • Corydalin
  • d-Corydaline
  • NSC 406036
  • UNII-08N392L8VX

Systematic Names

  • 13a-beta-Berbine, 2,3,9,10-tetramethoxy-13-alpha-methyl- (8CI)
  • 13abeta-Berbine, 2,3,9,10-tetramethoxy-13alpha-methyl- (8CI)
  • 6H-Dibenzo(a,g)quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-13-methyl-, (13S-trans)- (9CI)
  • Corydaline

Registry Numbers

CAS Registry Number

  • 518-69-4

FDA UNII

  • 08N392L8VX

System Generated Number

  • 0000518694

Structure Descriptors

InChI

1S/C22H27NO4/c1-13-15-6-7-18(24-2)22(27-5)17(15)12-23-9-8-14-10-19(25-3)20(26-4)11-16(14)21(13)23/h6-7,10-11,13,21H,8-9,12H2,1-5H3/t13-,21+/m0/s1

InChIKey

VRSRXLJTYQVOHC-YEJXKQKISA-N

Smiles

c12C[N@@]3[C@@H](c4cc(OC)c(cc4CC3)OC)[C@H](c2ccc(c1OC)OC)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 136mg/kg (136mg/kg)   Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 5, Pg. 163, 1946.