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Substance Name: Etofylline [INN:BAN]
RN: 519-37-9
UNII: L164909TBI
InChIKey: NWPRCRWQMGIBOT-UHFFFAOYSA-N

Note

  • Etophyllin appeared once in PubMed: Wien Med Wochenschr. 1986 May 15;136(9):213-8 as a combination drug with theophylline (spelt without e, theophllin).

Molecular Formula

  • C9-H12-N4-O3

Molecular Weight

  • 224.219
 

Classification Codes

  • Anti-Asthmatic Agents
  • Autonomic Agents
  • Bronchodilator Agents
  • Drug / Therapeutic Agent
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Respiratory System Agents
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Names and Synonyms

Name of Substance

  • Etofylline
  • Etofylline [INN:BAN]

Synonyms

  • 1,3-Dimethyl-7-(2-hydroxyethyl)xanthine
  • 5-26-14-00038 (Beilstein Handbook Reference)
  • 7-(2-Hydroxyethyl)-1,3-dimethylxanthine
  • 7-(2-Hydroxyethyl)theophylline
  • 7-(Hydroxyethyl)theophylline
  • 7-Theophyllineethanol
  • Aethophyllinum
  • Ascorphylline
  • Bio-phylline
  • BRN 0251760
  • Cordalin
  • Corophyllin-N
  • Dilaphyllin
  • EINECS 208-269-8
  • Etofilina
  • Etofilina [INN-Spanish]
  • Etofillina
  • Etofillina [DCIT]
  • Etofylline
  • Etofyllinum
  • Etofyllinum [INN-Latin]
  • Frekaphyllin
  • Hydroxyethyl theophylline
  • NSC 113373
  • OT
  • Oxphylline (amido)
  • Oxyaethyltheophyllin
  • Oxyaethyltheophyllin [German]
  • Oxyethyltheophylline
  • Oxyetophyllinum
  • Oxyphylline
  • Oxytheonyl
  • Phyllocormin N
  • Sklerodormal
  • Soluphylline
  • UNII-L164909TBI

Systematic Names

  • 1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxyethyl)-1,3-dimethyl- (9CI)
  • 3,7-Dihydro-7-(2-hydroxyethyl)-1,3-dimethyl-1H-purine-2,6-dione (9CI)
  • 7-(2-Hydroxyethyl)theophylline
  • Etofylline
  • Theophylline, 7-(2-hydroxyethyl)-

Registry Numbers

CAS Registry Number

  • 519-37-9

FDA UNII

  • L164909TBI

System Generated Number

  • 0000519379

Structure Descriptors

InChI

1S/C9H12N4O3/c1-11-7-6(8(15)12(2)9(11)16)13(3-4-14)5-10-7/h5,14H,3-4H2,1-2H3

InChIKey

NWPRCRWQMGIBOT-UHFFFAOYSA-N

Smiles

c12c(n(c(=O)n(c2=O)C)C)ncn1CCO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 400mg/kg (400mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 190, 1958.
mouse LD50 intravenous 344mg/kg (344mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 194, 1957.
mouse LD50 oral 400mg/kg (400mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1173, 1977.
mouse LD50 subcutaneous 400mg/kg (400mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

SKIN AND APPENDAGES (SKIN): SWEATING: OTHER
Arzneimittel-Forschung. Drug Research. Vol. 4, Pg. 649, 1954.
rat LD50 intravenous 486mg/kg (486mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 194, 1957.
rat LD50 oral 710mg/kg (710mg/kg) LIVER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 2023, 1980.
rat LD50 subcutaneous 176mg/kg (176mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 194, 1957.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 158 deg C   EXP
log P (octanol-water) -0.820 (none)   EST
Atmospheric OH Rate Constant 2.46E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.