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Substance Name: Gonadorelin hydrochloride [USAN:USP]
RN: 51952-41-1
UNII: 3PFC574ITA
InChIKey: UPRWQSQENCASAD-HBBGHHHDSA-N

Note

  • A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.

Molecular Formula

  • C55-H75-N17-O13.x-Cl-H

Molecular Weight

  • 1218.7644
 

Classification Code

  • Gonad-Stimulating Principle
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Names and Synonyms

Name of Substance

  • Gonadorelin hydrochloride [USAN:USP]
  • LH-RH hydrochloride

Synonyms

  • 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-; wL-leucyl-L-arginyl-L-prolylglycinamide hydrochloride. Note-Gonadorelin Hydrochloride is C55H75N17O13 as the monohydrochloride or the dihydrochloride or as a mixture of these
  • 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-L-prolylglycinamide hydrochloride
  • AY-24,031
  • Factrel
  • Gonadorelin HCl
  • Gonadorelin hydrochloride
  • UNII-3PFC574ITA

Systematic Name

  • Luteinizing hormone-releasing factor hydrochloride

Registry Numbers

CAS Registry Number

  • 51952-41-1

FDA UNII

  • 3PFC574ITA

Related Registry Number

  • 33515-09-2 (Parent)

System Generated Number

  • 0051952411

Molecular Formulas

Molecular Formula

  • C55-H75-N17-O13.x-Cl-H

Molecular Formula Fragments

  • C55-H75-N17-O13
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C55H75N17O13.ClH/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36;/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60);1H/t36-,37-,38-,39-,40-,41-,42-,43-;/m0./s1

InChIKey

UPRWQSQENCASAD-HBBGHHHDSA-N

Smiles

Cl.CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@@H]5CCC(=O)N5)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N6CCC[C@H]6C(=O)NCC(=O)N