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Substance Name: Prednisolone acetate [USP:JAN]
RN: 52-21-1
UNII: 8B2807733D
InChIKey: LRJOMUJRLNCICJ-JZYPGELDSA-N

Classification Codes

  • Anti-Inflammatory Agents
  • Drug / Therapeutic Agent
  • Glucocorticoid
  • Hormone
  • Reproductive Effect

Molecular Formula

  • C23-H30-O6

Molecular Weight

  • 402.484
 
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Names and Synonyms

Name of Substance

  • Prednisolone acetate
  • Prednisolone acetate [USP:JAN]

Synonyms

  • 11beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-acetate
  • 4-08-00-03468 (Beilstein Handbook Reference)
  • BRN 3111798
  • Cormalone
  • Cortipred
  • Delcort-E
  • Deltilen
  • Durapred
  • Econopred
  • Econopred plus
  • EINECS 200-134-1
  • Flo-Pred
  • Meticortelone
  • Meticortelone acetate
  • Nisolone
  • NSC 10966
  • Omnipred
  • Pred Forte
  • Pred Mild
  • Pred-Forte
  • Predalone 50
  • Prediacortine
  • Predicort
  • Prednelan-N
  • Prednidoren
  • Prednisolone 21-acetate
  • Prednisolone acetate
  • Predonine injection
  • Prenema
  • Pricortin
  • Ster
  • Sterane
  • Supercortyl
  • UNII-8B2807733D

Systematic Names

  • Prednisolone 21-acetate
  • Pregna-1,4-diene-3,20-dione, 11-beta,17,21-trihydroxy-, 21-acetate
  • Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-, 21-acetate (8CI)
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-, (11beta)-

Mixture Names

  • Blephamide Liquifilm
  • Blephamide S.O.P.
  • Cetapred Ointment
  • Isopto Cetapred
  • Metimyd
  • Mydrapred
  • Neo-Delta-Cortef
  • Poly-Pred
  • Pred-G Liquifilm
  • Pred-G S.O.P.
  • Vasocidin Ointment

Registry Numbers

CAS Registry Number

  • 52-21-1

FDA UNII

  • 8B2807733D

System Generated Number

  • 0000052211

Structure Descriptors

InChI

1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h6,8,10,16-18,20,26,28H,4-5,7,9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1

InChIKey

LRJOMUJRLNCICJ-JZYPGELDSA-N

Smiles

CC(=O)OCC(=O)[C@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)C=C[C@]34C)O)C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 subcutaneous 3500mg/kg (3500mg/kg)   Drugs in Japan Vol. 6, Pg. 713, 1982.
rat LD50 subcutaneous > 240mg/kg (240mg/kg)   Drugs in Japan Vol. 6, Pg. 713, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 238 dec deg C   EXP
log P (octanol-water) 2.4 (none)   EXP
Water Solubility 17.2 mg/L 25 EXP
Vapor Pressure 2.24E-13 mm Hg 25 EST
Henry's Law Constant 2.93E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 7.10E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.