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Substance Name: Morphine hydrochloride [USP:JAN]
RN: 52-26-6
UNII: J28GE0ROVX
InChIKey: XCKKIKBIPZJUET-VYKNHSEDSA-N

Note

  • The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.

Molecular Formula

  • C17-H19-N-O3.Cl-H

Molecular Weight

  • 321.802
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Morphine hydrochloride [USP:JAN]

Synonyms

  • Ampek
  • EINECS 200-136-2
  • Morphinan-3,6-alpha-diol, 7,8-didehydro-4,5-alpha-epoxy-17-methyl-, hydrochloride
  • Morphine chlorhydrate
  • Morphine chloride
  • Morphine HCl
  • Morphine hydrochloride
  • Theba-Intran
  • Thebametten
  • UNII-J28GE0ROVX

Systematic Names

  • Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl-, hydrochloride, (5-alpha,6-alpha)-
  • Morphine hydrochloride

Registry Numbers

CAS Registry Number

  • 52-26-6

FDA UNII

  • J28GE0ROVX

System Generated Number

  • 0000052266

Molecular Formulas

Molecular Formula

  • C17-H19-N-O3.Cl-H

Molecular Formula Fragments

  • C17-H19-N-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C17H19NO3.ClH/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;/h2-5,10-11,13,16,19-20H,6-8H2,1H3;1H/t10-,11+,13-,16-,17-;/m0./s1

InChIKey

XCKKIKBIPZJUET-VYKNHSEDSA-N

Smiles

c1(c2c3c(cc1)C[C@H]1[N@@](C)CC[C@@]43[C@@H]([C@H](C=C[C@H]14)O)O2)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 175mg/kg (175mg/kg)   Chemical and Pharmaceutical Bulletin. Vol. 7, Pg. 372, 1959.
guinea pig LD50 subcutaneous 340mg/kg (340mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 137, Pg. 375, 1962.
guinea pig LDLo intraarterial 60mg/kg (60mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
guinea pig LDLo intravenous 60mg/kg (60mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
mouse LD50 intracrebral 3500ug/kg (3.5mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 63(3), Pg. 93S, 1967.
mouse LD50 intraperitoneal 148mg/kg (148mg/kg)   British Journal of Pharmacology. Vol. 73, Pg. 887, 1981.
mouse LD50 intravenous 180mg/kg (180mg/kg)   Archives of Toxicology, Supplement. Vol. 7, Pg. 90, 1984.
mouse LD50 oral 745mg/kg (745mg/kg)   Japanese Journal of Pharmacology. Vol. 18, Pg. 406, 1968.
mouse LD50 parenteral 440mg/kg (440mg/kg)   Wakayama Medical Report. Vol. 26(4), Pg. 65, 1983.
mouse LD50 subcutaneous 354mg/kg (354mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1787, 1971.
rabbit LD50 intraperitoneal 500mg/kg (500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 60, Pg. 14, 1937.
rabbit LD50 intravenous 135mg/kg (135mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 85, Pg. 387, 1951.
rabbit LD50 subcutaneous 398mg/kg (398mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 66, Pg. 182, 1939.
rabbit LDLo oral 700mg/kg (700mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: FOOD INTAKE (ANIMAL)

BEHAVIORAL: MUSCLE WEAKNESS
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 14, Pg. 289, 1905.
rat LD50 intravenous 265mg/kg (265mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 115, Pg. 213, 1958.
rat LD50 oral 335mg/kg (335mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 221, Pg. 105, 1976.
rat LD50 subcutaneous 480mg/kg (480mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 115, Pg. 213, 1958.
rat LD50 unreported 310mg/kg (310mg/kg) BEHAVIORAL: ANALGESIA Pharmacological Research Communications. Vol. 5, Pg. 175, 1973.
rat LDLo intraspinal 2mg/kg (2mg/kg) BEHAVIORAL: ANALGESIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: IRRITABILITY
Acta Pharmacologica et Toxicologica. Vol. 56, Pg. 50, 1985.
women TDLo intraspinal 40ug/kg (0.04mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE
Israel Journal of Medical Sciences. Vol. 21, Pg. 855, 1985.
women TDLo parenteral 720ug/kg/3D-I (0.72mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Anesthesia and Analgesia Vol. 63, Pg. 1142, 1984.