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Substance Name: Pentolonium tartrate [INN]
RN: 52-62-0
UNII: 953357GACY
InChIKey: HSMKTIKKPMTUQH-WBPXWQEISA-L

Note

  • A nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension.

Molecular Formulas

  • C15-H32-N2.2C4-H5-O6
  • C15-H32-N2.2C4-H6-O6
  • C23-H42-N2-O12

Molecular Weight

  • 538.5868
 

Classification Codes

  • Antihypertensive Agents
  • Autonomic Agents
  • Cardiovascular Agents
  • Cholinergic Agents
  • Cholinergic Antagonists
  • Drug / Therapeutic Agent
  • Ganglionic Blockers
  • Neurotransmitter Agents
  • Nicotinic Antagonists
  • Peripheral Nervous System Agents
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Names and Synonyms

Results Name

  • Pentolonium tartrate [INN]

Name of Substance

  • Pentolinium tartrate [NF]
  • Pentolonium tartrate [INN]

MeSH Heading

  • Pentolinium tartrate

Synonyms

  • 1,1'-Pentamethylenebis(1-methylpyrrolidinium hydrogen tartrate)
  • 1,1'-Pentamethylenebis(1-methylpyrrolidinium tartrate)
  • Ansolysen
  • Ansolysen bitartrate
  • Ansolysen tartrate
  • Butanoic acid, 2,3-dihydroxy- (2R,3R)-, ion(1-), 1,1'-(1,5-pentanediyl)bis(1-methylpyrrolidinium) (2:1)
  • EINECS 200-146-7
  • MB 2050A
  • Pendine
  • Pentalinium tartrate
  • Pentamethylene-1,5-bis(1'-methylpyrrolidinium tartrate)
  • Pentapyrrolidium bitartrate
  • Pentilium
  • Pentolinio tartrato
  • Pentolinio tartrato [DCIT]
  • Pentolinium bitartrate
  • Pentolinium ditartrate
  • Pentolinium tartrate
  • Pentolonii tartras
  • Pentolonii tartras [INN-Latin]
  • Pentolonium tartrate
  • Pyrrolidinium 1,1'-(1,5-pentanediyl)bis-(1-methyl-, (R-(R*,R*))-2,3-dihydroxybutanedioate
  • Recuryl
  • Tartaric acid, ion(1-), 1,1'-pentamethylenebis(1-methylpyrrolidinium) (2:1)
  • Tartrate de pentolonium
  • Tartrate de pentolonium [INN-French]
  • Tartrato de pentolonio
  • Tartrato de pentolonio [INN-Spanish]
  • Tensilest
  • UNII-953357GACY

Systematic Names

  • Pentolonium tartrate
  • Pyrrolidinium 1,1'-(1,5-pentanediyl)bis-(1-methyl-, (R-(R*,R*))-2,3-dihydroxybutanedioate
  • Pyrrolidinium, 1,1'-(1,5-pentanediyl)bis(1-methyl-, salt with (R-(R*,R*))-2,3-dihydroxybutanedioic acid (1:2)
  • Pyrrolidinium, 1,1'-pentamethylenebis(1-methyl-, tartrate (1:2)

Registry Numbers

CAS Registry Number

  • 52-62-0

FDA UNII

  • 953357GACY

Other Registry Number

  • 56614-93-8

System Generated Number

  • 0000052620

Molecular Formulas

Molecular Formulas

  • C15-H32-N2.2C4-H5-O6
  • C15-H32-N2.2C4-H6-O6
  • C23-H42-N2-O12

Molecular Formula Fragments

  • C15-H32-N2
  • C4-H5-O6
  • C4-H6-O6
  • COMPONENT

Structure Descriptors

InChI

1S/C15H32N2.2C4H6O6/c1-16(12-6-7-13-16)10-4-3-5-11-17(2)14-8-9-15-17;2*5-1(3(7)8)2(6)4(9)10/h3-15H2,1-2H3;2*1-2,5-6H,(H,7,8)(H,9,10)/q+2;;/p-2/t;2*1-,2-/m.11/s1

InChIKey

HSMKTIKKPMTUQH-WBPXWQEISA-L

Smiles

C[N+]1(CCCC1)CCCCC[N+]2(CCCC2)C.[C@@H]([C@H](C(=O)[O-])O)(C(=O)O)O.[C@@H]([C@H](C(=O)[O-])O)(C(=O)O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 10mg/kg (10mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 46, Pg. 346, 1957.
mouse LD50 intraperitoneal 36mg/kg (36mg/kg)   Drugs in Japan Vol. 6, Pg. 780, 1982.
mouse LD50 intravenous 29mg/kg (29mg/kg)   Drugs in Japan Vol. 6, Pg. 780, 1982.
mouse LD50 oral 512mg/kg (512mg/kg)   Drugs in Japan Vol. 6, Pg. 780, 1982.
mouse LDLo subcutaneous 94mg/kg (94mg/kg)   Compilation of LD50 Values of New Drugs.
rat LD50 intraperitoneal 28900ug/kg (28.9mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 46, Pg. 346, 1957.
rat LD50 intravenous 50760ug/kg (50.76mg/kg)   Shionogi Kenkyusho Nenpo. Annual Report of Shionogi Research Laboratory. Vol. 10, Pg. 15, 1960.
rat LD50 oral 890mg/kg (890mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 120, Pg. 511, 1965.