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Substance Name: Trimipramine maleate [USAN:USP:JAN]
RN: 521-78-8
UNII: 269K6498LD
InChIKey: YDGHCKHAXOUQOS-BTJKTKAUSA-N

Note

  • Tricyclic antidepressant similar to IMIPRAMINE, but with more antihistaminic and sedative properties.

Molecular Formula

  • C20-H26-N2.C4-H4-O4

Molecular Weight

  • 410.511
 

Classification Codes

  • Antidepressant
  • Drug / Therapeutic Agent
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Trimipramine maleate [USAN:USP:JAN]

Synonyms

  • 5-(3-(Dimethylamino)-2-methylpropyl)-10,11-dihydro-5H-dibenz(b,f)azepine maleate (1:1)
  • 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N,beta-trimethyl-, (Z)-2-butenedioate (1:1)
  • EINECS 208-318-3
  • NSC 758386
  • Surmontil
  • Surmontil maleate
  • Trimeprimine maleate
  • Trimeprimine monomaleate
  • Trimipramine acid maleate
  • Trimipramine maleate
  • Trimipramini maleas
  • Trimipramium maleinicum
  • UNII-269K6498LD

Systematic Names

  • 5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(dimethylamino)-2-methylpropyl)-, maleate (1:1)
  • 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N,beta-trimethyl-, (2Z)-2-butenedioate (1:1)
  • 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N,beta-trimethyl-, (Z)-2-butenedioate (1:1)
  • Trimipramine hydrogen maleate

Registry Numbers

CAS Registry Number

  • 521-78-8

FDA UNII

  • 269K6498LD

Related Registry Number

  • 739-71-9 (Parent)

System Generated Number

  • 0000521788

Molecular Formulas

Molecular Formula

  • C20-H26-N2.C4-H4-O4

Molecular Formula Fragments

  • C20-H26-N2
  • C4-H4-O4
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C20H26N2.C4H4O4/c1-16(14-21(2)3)15-22-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)22;5-3(6)1-2-4(7)8/h4-11,16H,12-15H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChIKey

YDGHCKHAXOUQOS-BTJKTKAUSA-N

Smiles

CC(CN(C)C)CN1c2ccccc2CCc3ccccc13.OC(=O)\C=C/C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 223mg/kg (223mg/kg)   Drugs in Japan Vol. -, Pg. 876, 1995.
mouse LD50 intraperitoneal 140mg/kg (140mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
mouse LD50 intravenous 40mg/kg (40mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
mouse LD50 oral 425mg/kg (425mg/kg)   Drugs in Japan Vol. 6, Pg. 526, 1982.
mouse LD50 subcutaneous 240mg/kg (240mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rabbit LD50 intravenous 27mg/kg (27mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 25, Pg. 158, 1965.
rabbit LD50 intravenous 27mg/kg (27mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
British Journal of Pharmacology and Chemotherapy. Vol. 25, Pg. 158, 1965.
rat LD50 intraperitoneal 150mg/kg (150mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rat LD50 intravenous 38mg/kg (38mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rat LD50 oral 800mg/kg (800mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rat LD50 subcutaneous 308mg/kg (308mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.