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Substance Name: Galosemide [INN]
RN: 52157-91-2
UNII: J8QB2W9908
InChIKey: GNWHIAXZYUDAFX-UHFFFAOYSA-N

Note

  • Potent diuretic in rats but inactive in man due to rapid hydrolysis of NH-CO bond.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C15-H14-F3-N3-O3-S

Molecular Weight

  • 373.354
 
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Names and Synonyms

Name of Substance

  • Gallosemide
  • Galosemide [INN]

Synonyms

  • 5-22-14-00461 (Beilstein Handbook Reference)
  • BRN 0501125
  • C 2124
  • Galosemida
  • Galosemida [INN-Spanish]
  • Galosemide
  • Galosemidum
  • Galosemidum [INN-Latin]
  • N-((4-((3-(Trifluoromethyl)phenyl)amino)-3-pyridinyl)sulfonyl)propanamide
  • N-((4-(alpha,alpha,alpha-Trifluoro-3-toluidino)-3-pyridyl)sulfonyl)propionamid
  • N-((4-(alpha,alpha,alpha-Trifluoro-m-toluidino)-3-pyridyl)sulfonyl)propionamide
  • UNII-J8QB2W9908

Systematic Names

  • N-((4-(alpha,alpha,alpha-Trifluoro-m-toluidino)-3-pyridyl)sulfonyl)propionamide
  • Propanamide, N-((4-((3-(trifluoromethyl)phenyl)amino)-3-pyridinyl)sulfonyl)-

Registry Numbers

CAS Registry Number

  • 52157-91-2

FDA UNII

  • J8QB2W9908

System Generated Number

  • 0052157912

Structure Descriptors

InChI

1S/C15H14F3N3O3S/c1-2-14(22)21-25(23,24)13-9-19-7-6-12(13)20-11-5-3-4-10(8-11)15(16,17)18/h3-9H,2H2,1H3,(H,19,20)(H,21,22)

InChIKey

GNWHIAXZYUDAFX-UHFFFAOYSA-N

Smiles

c1c(c(S(=O)(=O)NC(=O)CC)cnc1)Nc1cccc(C(F)(F)F)c1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LD50 unreported > 1gm/kg (1000mg/kg)   Annales Pharmaceutiques Francaises. Vol. 32, Pg. 657, 1974.