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Substance Name: Phosphinic amide, N,N'-(1,4-phenylenebis(1-aziridinylmethylidyne))bis(P,P-bis(1-aziridinyl)-
RN: 52161-27-0
InChIKey: MQSLKXHYZGHYSS-FLFKKZLDSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C20-H28-N8-O2-P2

Molecular Weight

  • 474.4432
 
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Names and Synonyms

Synonyms

  • BRN 1360788
  • N,N'-(1,4-Phenylenebis(1-aziridinylmethylidyne))bis(P,P-bis(1-aziridinyl)phosphinic amide)

Systematic Name

  • Phosphinic amide, N,N'-(1,4-phenylenebis(1-aziridinylmethylidyne))bis(P,P-bis(1-aziridinyl)-

Registry Numbers

CAS Registry Number

  • 52161-27-0

System Generated Number

  • 0052161270

Structure Descriptors

InChI

1S/C20H28N8O2P2/c29-31(25-9-10-25,26-11-12-26)19(23-5-6-23)21-17-1-2-18(4-3-17)22-20(24-7-8-24)32(30,27-13-14-27)28-15-16-28/h1-4H,5-16H2/b21-19+,22-20+

InChIKey

MQSLKXHYZGHYSS-FLFKKZLDSA-N

Smiles

c1c(ccc(c1)/N=C(/P(=O)(N2CC2)N3CC3)\N4CC4)/N=C(/P(=O)(N5CC5)N6CC6)\N7CC7

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 subcutaneous 79mg/kg (79mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

BLOOD: CHANGES IN SPLEEN

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"
Farmakologiya i Toksikologiya Vol. 8, Pg. 73, 1973.
rabbit LD50 intravenous 25500ug/kg (25.5mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"

BLOOD: CHANGES IN SPLEEN

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Farmakologiya i Toksikologiya Vol. 8, Pg. 73, 1973.
rat LD50 subcutaneous 75mg/kg (75mg/kg) BLOOD: CHANGES IN SPLEEN

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"
Farmakologiya i Toksikologiya Vol. 8, Pg. 73, 1973.