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Substance Name: Pyrathiazine hydrochloride
RN: 522-25-8
UNII: X0SMC42Q5O
InChIKey: VDOLRBJLUIFCGO-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C18-H20-N2-S.Cl-H

Molecular Weight

  • 332.8969
 
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Names and Synonyms

Name of Substance

  • Pyrathiazine hydrochloride

Synonyms

  • 10-(2-(1-Pyrrolidyl)ethyl)phenothiazine hydrochloride
  • N-(2-Pyrrolidinoethyl)phenothiazine hydrochloride
  • NSC 62360
  • Pyrathiazine HCl
  • Pyrathiazine hydrochloride
  • Pyrrolazote
  • Pyrrolazote abergic
  • Pyrrolazote hydrochloride
  • Rolazote
  • UNII-X0SMC42Q5O

Systematic Names

  • 10-(2-(1-Pyrrolidinyl)ethyl)phenothiazine hydrochloride
  • 10H-Phenothiazine, 10-(2-(1-pyrrolidinyl)ethyl)-, monohydrochloride
  • Phenothiazine, 10-(2-(1-pyrrolidinyl)ethyl)-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 522-25-8

FDA UNII

  • X0SMC42Q5O

Related Registry Number

  • 84-08-2 (Parent)

System Generated Number

  • 0000522258

Molecular Formulas

Molecular Formula

  • C18-H20-N2-S.Cl-H

Molecular Formula Fragments

  • C18-H20-N2-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C18H20N2S.ClH/c1-3-9-17-15(7-1)20(14-13-19-11-5-6-12-19)16-8-2-4-10-18(16)21-17;/h1-4,7-10H,5-6,11-14H2;1H

InChIKey

VDOLRBJLUIFCGO-UHFFFAOYSA-N

Smiles

c1ccc2c(c1)N(c3ccccc3S2)CCN4CCCC4.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 177mg/kg (177mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 44, 1972.
mouse LD50 intravenous 37mg/kg (37mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 197, 1948.
mouse LD50 subcutaneous 1340mg/kg (1340mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 197, 1948.
rabbit LD50 intravenous 36mg/kg (36mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 197, 1948.
rat LD50 intravenous 26mg/kg (26mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 197, 1948.