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Substance Name: Thiethylperazine malate [USP]
RN: 52239-63-1
UNII: HP46XK89XB
InChIKey: GTHHLZDYRHLACN-UHFFFAOYSA-N

Note

  • A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457)

Molecular Formula

  • C22-H29-N3-S2.2C4-H6-O5

Molecular Weight

  • 667.7969
 

Classification Codes

  • Anti-Emetic
  • Antiemetics
  • Dopamine Antagonists
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Names and Synonyms

Name of Substance

  • Thiethylperazine dimalate
  • Thiethylperazine malate [USP]

Synonyms

  • 10H-Phenothiazine, 2-(ethylthio)-10-(3-(4-methyl-1-piperazinyl)propyl)-, 2-hydroxy-1,4-butanedioate (1:2)
  • 2-(Ethylthio)-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine malate (1:2)
  • EINECS 257-780-2
  • Norzine Ampuls
  • Thiethylperazine malate
  • Thietylperazine malate
  • Torecan
  • UNII-HP46XK89XB

Systematic Names

  • 10H-Phenothiazine, 2-(ethylthio)-10-(3-(4-methyl-1-piperazinyl)propyl)-, 2-hydroxy-1,4-butanedioate (1:2)
  • Butanedioic acid, hydroxy-, compd. with 2-(ethylthio)-10-(3-(4-methyl-1-piperazinyl)propyl)-10H-phenothiazine (2:1)
  • Malic acid, compound with 2-(ethylthio)-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine (2:1)

Registry Numbers

CAS Registry Number

  • 52239-63-1

FDA UNII

  • HP46XK89XB

Related Registry Number

  • 1420-55-9 (Parent)

System Generated Number

  • 0052239631

Molecular Formulas

Molecular Formula

  • C22-H29-N3-S2.2C4-H6-O5

Molecular Formula Fragments

  • C22-H29-N3-S2
  • C4-H6-O5
  • COMPONENT

Structure Descriptors

InChI

1S/C22H29N3S2.2C4H6O5/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24;2*5-2(4(8)9)1-3(6)7/h4-5,7-10,17H,3,6,11-16H2,1-2H3;2*2,5H,1H2,(H,6,7)(H,8,9)

InChIKey

GTHHLZDYRHLACN-UHFFFAOYSA-N

Smiles

CCSc1ccc2c(c1)N(c3ccccc3S2)CCCN4CCN(CC4)C.C(C(C(=O)O)O)C(=O)O.C(C(C(=O)O)O)C(=O)O