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Substance Name: Ethybenztropine [USAN]
RN: 524-83-4
UNII: G1X2X9N95N
InChIKey: PHTMLLGDZBZXMW-AERCQKQUSA-N

Classification Code

  • Anticholinergic

Molecular Formula

  • C22-H27-N-O

Molecular Weight

  • 321.4613
 
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Names and Synonyms

Name of Substance

  • Ethybenztropine
  • Ethybenztropine [USAN]
  • Etybenzatropine [INN]

Synonyms

  • 3-(Diphenylmethoxy)-8-ethylnortropane
  • 3-alpha-(Diphenylmethoxy)-8-ethyl-1-alpha-H,5-alpha-H-nortropane
  • 3alpha-(Diphenylmethoxy)-8-ethyl-1alphaH,5alphaH-nortropane
  • 8-Azabicyclo(3.2.1)octane, 3-(diphenylmethoxy)-8-ethyl-, endo-
  • Ethybenztropine
  • Ethylbenatropine
  • Ethylbenztropine
  • Etibenzatropina
  • Etibenzatropina [DCIT]
  • Etybenzatropine
  • Etybenzatropinum
  • Etybenzatropinum [INN-Latin]
  • Etybenztropinum
  • N-Ethylnortropine benzhydryl ether
  • Panolid
  • UK-738
  • UNII-G1X2X9N95N

Systematic Names

  • 8-Azabicyclo(3.2.1)octane, 3-(diphenylmethoxy)-8-ethyl-, endo-
  • Nortropane, 3-(diphenylmethoxy)-8-ethyl-

Registry Numbers

CAS Registry Number

  • 524-83-4

FDA UNII

  • G1X2X9N95N

System Generated Number

  • 0000524834

Structure Descriptors

InChI

1S/C22H27NO/c1-2-23-19-13-14-20(23)16-21(15-19)24-22(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h3-12,19-22H,2,13-16H2,1H3/t19-,20+,21+

InChIKey

PHTMLLGDZBZXMW-AERCQKQUSA-N

Smiles

CCN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c3ccccc3)c4ccccc4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 12mg/kg (12mg/kg) AUTONOMIC NERVOUS SYSTEM: PARASYMPATHOLYTIC European Journal of Pharmacology. Vol. 9, Pg. 304, 1970.
mouse LDLo oral 66mg/kg (66mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 228, 1972.
rabbit LDLo intravenous 6mg/kg (6mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 228, 1972.
rabbit LDLo oral 215mg/kg (215mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 228, 1972.
rat LD50 intravenous 18500ug/kg (18.5mg/kg)   French Medicament Patent Document. Vol. #2235M,
rat LDLo oral 560mg/kg (560mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 228, 1972.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 4.770 (none)   EST
Atmospheric OH Rate Constant 9.34E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.