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Substance Name: Flunarizine [INN:BAN]
RN: 52468-60-7
UNII: R7PLA2DM0J
InChIKey: SMANXXCATUTDDT-QPJJXVBHSA-N

Note

  • Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.

Molecular Formula

  • C26-H26-F2-N2

Molecular Weight

  • 404.5014
 

Classification Codes

  • Anticonvulsants
  • Calcium Channel Blockers
  • Cardiovascular Agents
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Histamine Agents
  • Histamine Antagonists
  • Histamine H1 Antagonists
  • Human Data
  • Membrane Transport Modulators
  • Neurotransmitter Agents
  • Vasodilator Agents

Names and Synonyms

Name of Substance

  • Flunarizine
  • Flunarizine [INN:BAN]

MeSH Heading

  • Flunarizine

Synonyms

  • (E)-1-(Bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)piperazine
  • EINECS 257-937-5
  • Flunarizina
  • Flunarizina [INN-Spanish]
  • Flunarizine
  • Flunarizinum
  • Flunarizinum [INN-Latin]
  • Narzine
  • Sibelium
  • UNII-R7PLA2DM0J

Systematic Names

  • Flunarizine
  • Piperazine, 1-(bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)-, (E)-

Registry Numbers

CAS Registry Number

  • 52468-60-7

FDA UNII

  • R7PLA2DM0J

Related Registry Number

  • 30484-77-6 (di-hydrochloride)

System Generated Number

  • 0052468607

Structure Descriptors

InChI

1S/C26H26F2N2/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21/h1-15,26H,16-20H2/b7-4+

InChIKey

SMANXXCATUTDDT-QPJJXVBHSA-N

Smiles

c1ccc(cc1)/C=C/CN2CCN(CC2)C(c3ccc(cc3)F)c4ccc(cc4)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 4286ug/kg/30D (4.286mg/kg) BEHAVIORAL: TREMOR Neurology. Vol. 37, Pg. 881, 1987.
mouse LD50 oral 960mg/kg (960mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 1103, 1987.
women TDLo oral 18mg/kg/90D-I (18mg/kg) BEHAVIORAL: TREMOR Neurology. Vol. 37, Pg. 881, 1987.
women TDLo oral 73mg/kg/1Y-I (73mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Italian Journal of Neurological Sciences. Vol. 10, Pg. 89, 1989.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 5.78 (none)   EXP
Water Solubility 0.339 mg/L 25 EST
Vapor Pressure 1.68E-09 mm Hg 25 EST
Henry's Law Constant 5.53E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.66E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.