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Substance Name: Sulfaphenazole [INN:BAN:JAN]
RN: 526-08-9
UNII: 0J8L4V3F81
InChIKey: QWCJHSGMANYXCW-UHFFFAOYSA-N

Note

  • A sulfonilamide anti-infective agent.

Classification Codes

  • Anti-Infective Agents
  • Drug / Therapeutic Agent

Molecular Formula

  • C15-H14-N4-O2-S

Molecular Weight

  • 314.3676
 
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Names and Synonyms

Name of Substance

  • Sulfaphenazole
  • Sulfaphenazole [INN:BAN:JAN]

MeSH Heading

  • Sulfaphenazole

Synonyms

  • 1-Phenyl-5-sulfanilamidopyrazole
  • 3-(p-Aminobenzenesulfonamido)-2-phenylpyrazole
  • 4-Amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
  • 5-25-09-00415 (Beilstein Handbook Reference)
  • 5-Sulfanilamido-1-phenylpyrazole
  • BRN 0308518
  • Depocid
  • Depotsulfonamide
  • Eftolon
  • EINECS 208-384-3
  • Firmazolo
  • Inamil
  • Isarol
  • Merian
  • Microtan pirazolo
  • N'-(1-Phenylpyrazol-5-yl)sulfanilamide
  • N(sup 1)-(1-Phenylpyrazol-5-yl)sulfanilamide
  • Orisul
  • Paidazolo
  • Plisulfan
  • Raziosulfa
  • Solfafenazolo
  • Solfafenazolo [DCIT]
  • Sulfabid
  • Sulfafenazol
  • Sulfafenazol [INN-Spanish]
  • Sulfafenazolo
  • Sulfafenazolo [Italian]
  • Sulfaphenazol
  • Sulfaphenazol [INN-French]
  • Sulfaphenazole
  • Sulfaphenazolum
  • Sulfaphenazolum [INN-Latin]
  • Sulfaphenazon
  • Sulfaphenylpipazol
  • Sulfaphenylpyrazole
  • Sulphaphenazole
  • Sulphenazole
  • UNII-0J8L4V3F81

Systematic Names

  • Benzenesulfonamide, 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)-
  • N1-(1-Phenylpyrazol-5-yl)sulfanilamide
  • Sulfanilamide, N(sup 1)-(1-phenylpyrazol-5-yl)- (8CI)
  • Sulfaphenazole

Registry Numbers

CAS Registry Number

  • 526-08-9

FDA UNII

  • 0J8L4V3F81

System Generated Number

  • 0000526089

Structure Descriptors

InChI

1S/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2

InChIKey

QWCJHSGMANYXCW-UHFFFAOYSA-N

Smiles

n1(c(NS(=O)(=O)c2ccc(cc2)N)ccn1)c1ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 470mg/kg (470mg/kg)   Drugs in Japan Vol. 6, Pg. 387, 1982.
mouse LD50 oral 3016mg/kg (3016mg/kg)   Minerva Medica. Vol. 52, Pg. 1789, 1961.
mouse LD50 subcutaneous 660mg/kg (660mg/kg)   Drugs in Japan Vol. 6, Pg. 387, 1982.
rabbit LD50 intravenous 440mg/kg (440mg/kg)   Drugs in Japan Vol. 6, Pg. 387, 1982.
rabbit LD50 subcutaneous 950mg/kg (950mg/kg)   Drugs in Japan Vol. 6, Pg. 387, 1982.
rat LD50 intravenous 525mg/kg (525mg/kg)   Drugs in Japan Vol. 6, Pg. 387, 1982.
rat LD50 subcutaneous 900mg/kg (900mg/kg)   Drugs in Japan Vol. 6, Pg. 387, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 181 deg C   EXP
log P (octanol-water) 1.52 (none)   EXP
Water Solubility 1500 mg/L 25 EXP
Vapor Pressure 2.02E-10 mm Hg 25 EST
Henry's Law Constant 2.05E-16 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.00E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.