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Substance Name: Osalmid [INN:JAN]
RN: 526-18-1
UNII: 89741L759Z
InChIKey: LGCMKPRGGJRYGM-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C13-H11-N-O3

Molecular Weight

  • 229.2339
 
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Names and Synonyms

Name of Substance

  • Osalmid
  • Osalmid [INN:JAN]
  • Osalmide

Synonyms

  • 2-Hydroxy-N-(4-hydroxyphenyl)benzamide
  • 3-13-00-01137 (Beilstein Handbook Reference)
  • 4'-Hydroxysalicylanilide
  • Auxobil
  • Bilene
  • Bilocol
  • BRN 2941480
  • Dribazil
  • Driol
  • Driol-labaz
  • EINECS 208-385-9
  • Enidran
  • Hydroxyphenyl salicylamide
  • L 1718
  • L-1718
  • N'-Salicyloyl-p-aminophenol
  • N-(4-Hydroxyphenyl)salicylamide
  • N-(p-Hydroxyphenyl)salicylamide
  • NSC 93960
  • Oksafenamid
  • Osalmid
  • Osalmida
  • Osalmida [INN-Spanish]
  • Osalmide
  • Osalmide [INN-French]
  • Osalmidum
  • Osalmidum [INN-Latin]
  • Oxaphenamid
  • Oxaphenamide
  • Oxaphenamidum
  • p'-Hydroxysalicylanilide
  • p-Hydroxyphenylsalicylamide
  • PHPS
  • Salmidochol
  • Saryuurin
  • UNII-89741L759Z

Systematic Names

  • 4'-Hydroxysalicylanilide
  • Benzamide, 2-hydroxy-N-(4-hydroxyphenyl)-
  • Benzamide, 2-hydroxy-N-(4-hydroxyphenyl)- (9CI)
  • Osalmid
  • Salicylanilide, 4'-hydroxy-

Registry Numbers

CAS Registry Number

  • 526-18-1

FDA UNII

  • 89741L759Z

System Generated Number

  • 0000526181

Structure Descriptors

InChI

1S/C13H11NO3/c15-10-7-5-9(6-8-10)14-13(17)11-3-1-2-4-12(11)16/h1-8,15-16H,(H,14,17)

InChIKey

LGCMKPRGGJRYGM-UHFFFAOYSA-N

Smiles

c1ccc(c(c1)C(=O)Nc2ccc(cc2)O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 517mg/kg (517mg/kg)   Drugs in Japan Vol. 6, Pg. 159, 1982.
mouse LD50 intravenous 180mg/kg (180mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03234,
mouse LD50 oral 1050mg/kg (1050mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Japanese Journal of Pharmacology. Vol. 22, Pg. 235, 1972.
mouse LD50 subcutaneous 1900mg/kg (1900mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 116, Pg. 154, 1958.
rat LD50 intraperitoneal 1484mg/kg (1484mg/kg)   Drugs in Japan Vol. -, Pg. 290, 1995.
rat LD50 oral 6702mg/kg (6702mg/kg)   Drugs in Japan Vol. 6, Pg. 159, 1982.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 6, Pg. 159, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 179 deg C   EXP
log P (octanol-water) 2.470 (none)   EST
Atmospheric OH Rate Constant 4.81E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.