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Substance Name: Bunazosin hydrochloride [JAN]
RN: 52712-76-2
UNII: 18V54TZ7U6
InChIKey: NBGBEUITCPENLJ-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C19-H27-N5-O3.Cl-H

Molecular Weight

  • 409.9152
 
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Names and Synonyms

Name of Substance

  • Bunazosin hydrochloride
  • Bunazosin hydrochloride [JAN]

Synonyms

  • 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(1-oxobutyl)hexahydro-1H-1,4-diazepine monohydrochloride
  • 4-Amino-2-(4-butanoylhexahydro-1H-1,4-diazepin-1-yl)-6,7-dimethoxyquinazoline hydrochloride
  • Bunazocine hydrochloride
  • Bunazosin HCl
  • Bunazosin hydrochloride
  • DDQ
  • DDQ (pharmaceutical)
  • Detantol
  • E-643
  • E643
  • UNII-18V54TZ7U6

Systematic Name

  • 1H-1,4-Diazepine, hexahydro-1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1-oxobutyl)-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 52712-76-2

FDA UNII

  • 18V54TZ7U6

Related Registry Number

  • 80755-51-7 (Parent)

System Generated Number

  • 0052712762

Molecular Formulas

Molecular Formula

  • C19-H27-N5-O3.Cl-H

Molecular Formula Fragments

  • C19-H27-N5-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C19H27N5O3.ClH/c1-4-6-17(25)23-7-5-8-24(10-9-23)19-21-14-12-16(27-3)15(26-2)11-13(14)18(20)22-19;/h11-12H,4-10H2,1-3H3,(H2,20,21,22);1H

InChIKey

NBGBEUITCPENLJ-UHFFFAOYSA-N

Smiles

CCCC(=O)N1CCCN(CC1)c2nc3cc(c(cc3c(n2)N)OC)OC.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 598mg/kg (598mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 843, 1983.
mouse LD50 intravenous 57mg/kg (57mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: TREMOR
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 843, 1983.
mouse LD50 oral 1201mg/kg (1201mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 843, 1983.
mouse LD50 subcutaneous 630mg/kg (630mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 843, 1983.
rat LD50 intramuscular 152mg/kg (152mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 843, 1983.
rat LD50 intravenous 50mg/kg (50mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 843, 1983.
rat LD50 oral 980mg/kg (980mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 843, 1983.
rat LD50 subcutaneous 365mg/kg (365mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 843, 1983.