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Substance Name: Zoloperone [INN]
RN: 52867-74-0
UNII: 3YU9TET43B
InChIKey: FCMGKQUKZIJJSH-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formulas

  • C22-H21-F-N3-O3
  • C22-H24-F-N3-O3

Molecular Weight

  • 397.4476
 
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Names and Synonyms

Name of Substance

  • LR 511
  • Zoloperone [INN]

Synonyms

  • 4-(4-Fluorophenyl)-5-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-2(3H)-oxazolone
  • 4-(p-Fluorophenyl)-5-(2-(4-(o-methoxyphenyl)-1-piperazinyl)ethyl)-4-oxazolin-2-one
  • BRN 1182380
  • LR 511
  • UNII-3YU9TET43B
  • Zoloperona
  • Zoloperona [INN-Spanish]
  • Zoloperone
  • Zoloperonum
  • Zoloperonum [INN-Latin]

Systematic Names

  • 2(3H)-Oxazolone, 4-(4-fluorophenyl)-5-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-
  • 4-(4-Fluorophenyl)-5-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-2(3H)-oxazolone
  • 4-(p-Fluorophenyl)-5-(2-(4-(o-methoxyphenyl)-1-piperazinyl)ethyl)-4-oxazolin-2-one

Registry Numbers

CAS Registry Number

  • 52867-74-0

FDA UNII

  • 3YU9TET43B

System Generated Number

  • 0052867740

Structure Descriptors

InChI

1S/C22H24FN3O3/c1-28-19-5-3-2-4-18(19)26-14-12-25(13-15-26)11-10-20-21(24-22(27)29-20)16-6-8-17(23)9-7-16/h2-9H,10-15H2,1H3,(H,24,27)

InChIKey

FCMGKQUKZIJJSH-UHFFFAOYSA-N

Smiles

COc1ccccc1N2CCN(CC2)CCc3c([nH]c(=O)o3)c4ccc(cc4)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD intraperitoneal > 1gm/kg (1000mg/kg)   Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 15, Pg. 485, 1977.
dog LD oral > 1gm/kg (1000mg/kg)   Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 15, Pg. 485, 1977.
mouse LD oral > 2gm/kg (2000mg/kg)   Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 15, Pg. 485, 1977.
mouse LD50 intraperitoneal > 2gm/kg (2000mg/kg)   Journal of Medicinal Chemistry. Vol. 32, Pg. 2241, 1989.
rabbit LD intraperitoneal > 1gm/kg (1000mg/kg)   Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 15, Pg. 485, 1977.
rabbit LD oral > 1gm/kg (1000mg/kg)   Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 15, Pg. 485, 1977.
rat LD intraperitoneal > 1gm/kg (1000mg/kg)   Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 15, Pg. 485, 1977.
rat LD oral > 2gm/kg (2000mg/kg)   Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 15, Pg. 485, 1977.