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Substance Name: Prednisone [USP:INN:BAN]
RN: 53-03-2
UNII: VB0R961HZT
InChIKey: XOFYZVNMUHMLCC-ZPOLXVRWSA-N

Note

  • A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.

Molecular Formula

  • C21-H26-O5

Molecular Weight

  • 358.4314
 

Classification Codes

Classification Codes

  • Adrenal Cortex Hormones
  • Anti-Inflammatory Agents
  • Antineoplastic Agents
  • Antineoplastic Agents, Hormonal
  • Drug / Therapeutic Agent
  • Glucocorticoid
  • Glucocorticoids
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 3

Names and Synonyms

Name of Substance

  • Prednisone
  • Prednisone [USP:INN:BAN]

MeSH Heading

  • Prednisone

Synonyms

  • 1,2-Dehydrocortisone
  • 1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
  • 1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
  • 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
  • Adasone
  • AI3-52939
  • Ancortone
  • Apo-Prednisone
  • Bicortone
  • Cartancyl
  • CCRIS 2646
  • Colisone
  • Cortan
  • Cortidelt
  • Cotone
  • Dacorten
  • Dacortin
  • Decortancyl
  • Decortin
  • Decortisyl
  • Dekortin
  • Dellacort
  • Dellacort A
  • delta cortelan
  • delta E
  • delta(sup 1)-Cortisone
  • delta(sup 1)-Dehydrocortisone
  • delta-1-Cortisone
  • delta-1-Dehydrocortisone
  • delta-Cortelan
  • delta-Cortisone
  • delta-Dome
  • Deltacortene
  • Deltacortisone
  • Deltacortone
  • Deltasone
  • Deltison
  • Deltisona
  • Deltra
  • Di-adreson
  • DiAdreson
  • Econosone
  • EINECS 200-160-3
  • Encorton
  • Encortone
  • Enkorton
  • Fernisone
  • Fiasone
  • Hostacortin
  • HSDB 3168
  • IN-Sone
  • Incocortyl
  • Juvason
  • Liquid Pred
  • Lisacort
  • Lodotra
  • Lodtra
  • Me-Korti
  • Metacortandracin
  • Meticorten
  • Meticorten (Veterinary)
  • NCI-C04897
  • Nisona
  • Nizon
  • Novoprednisone
  • NSC 10023
  • Nurison
  • Orasone
  • Origen Prednisone
  • Panafcort
  • Panasol
  • Paracort
  • Parmenison
  • Pehacort
  • Predeltin
  • Prednicen-M
  • Prednicorm
  • Prednicort
  • Prednicot
  • Prednidib
  • Prednilonga
  • Prednison
  • Prednisona
  • Prednisona [INN-Spanish]
  • Prednisone
  • Prednisone intensol
  • Prednisonum
  • Prednisonum [INN-Latin]
  • Prednitone
  • Prednizon
  • Prednovister
  • Pregna-1,4-diene-3,11,20-trione monohydrate, 17,21-dihydroxy-
  • Presone
  • Pronison
  • Rayos
  • Rectodelt
  • Retrocortine
  • Servisone
  • SK-Prednisone
  • Sone
  • Sterapred
  • Supercortil
  • U 6020
  • Ultracorten
  • Ultracortene
  • UNII-VB0R961HZT
  • Winpred
  • Wojtab
  • Zenadrid
  • Zenadrid (veterinary)

Systematic Names

  • Prednisone
  • Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-

Superlist Name

  • Prednisone

Mixture Name

  • Metrevet (Veterinary)

Registry Numbers

CAS Registry Number

  • 53-03-2

FDA UNII

  • VB0R961HZT

Other Registry Number

  • 68-59-7

System Generated Number

  • 0000053032

Structure Descriptors

InChI

InChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1

InChIKey

XOFYZVNMUHMLCC-ZPOLXVRWSA-N

Smiles

C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man LDLo oral 400ug/kg (0.4mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Irish Journal of Medical Science. Vol. 155, Pg. 234, 1986.
man TDLo oral 857ug/kg (0.857mg/kg) PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE Neurology. Vol. 36, Pg. 729, 1986.
mouse LD50 intramuscular 600mg/kg (600mg/kg)   Cancer Research. Vol. 42, Pg. 122, 1982.
mouse LD50 intraperitoneal 135mg/kg (135mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse LD50 subcutaneous 101mg/kg (101mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
women TDLo oral 2400ug/kg/2D- (2.4mg/kg) PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE Neurology. Vol. 36, Pg. 729, 1986.
women TDLo unreported 113mg/kg (113mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

BLOOD: HEMORRHAGE		 JAMA, Journal of the American Medical Association. Vol. 243, Pg. 1260, 1980.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 234 dec deg C   EXP
log P (octanol-water) 1.46 (none)   EXP
Water Solubility 312 mg/L 25 EST
Vapor Pressure 5.09E-13 mm Hg 25 EST
Henry's Law Constant 2.83E-10 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 6.79E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.