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Substance Name: Prednisone [USP:INN:BAN]
RN: 53-03-2
UNII: VB0R961HZT
InChIKey: XOFYZVNMUHMLCC-ZPOLXVRWSA-N
Note
- A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
Molecular Formula
- C21-H26-O5
Molecular Weight
- 358.4314
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Adrenal Cortex Hormones
- Anti-Inflammatory Agents
- Antineoplastic Agents
- Antineoplastic Agents, Hormonal
- Antiviral (COVID-19)
- Drug / Therapeutic Agent
- Glucocorticoid
- Glucocorticoids
- Hormones
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Human Data
- Mutation Data
- Reproductive Effect
- Tumor Data
Superlist Classification Code
- Overall Carcinogenic Evaluation: Group 3
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Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Prednisone
- Prednisone [USP:INN:BAN]
MeSH Heading
- Prednisone
Synonyms
- 1,2-Dehydrocortisone
- 1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
- 1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
- 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
- Adasone
- AI3-52939
- Ancortone
- Apo-Prednisone
- Bicortone
- Cartancyl
- CCRIS 2646
- Colisone
- Cortan
- Cortidelt
- Cotone
- Dacorten
- Dacortin
- Decortancyl
- Decortin
- Decortisyl
- Dekortin
- Dellacort
- Dellacort A
- delta cortelan
- delta E
- delta(sup 1)-Cortisone
- delta(sup 1)-Dehydrocortisone
- delta-1-Cortisone
- delta-1-Dehydrocortisone
- delta-Cortelan
- delta-Cortisone
- delta-Dome
- Deltacortene
- Deltacortisone
- Deltacortone
- Deltasone
- Deltison
- Deltisona
- Deltra
- Di-adreson
- DiAdreson
- Econosone
- EINECS 200-160-3
- Encorton
- Encortone
- Enkorton
- Fernisone
- Fiasone
- Hostacortin
- HSDB 3168
- IN-Sone
- Incocortyl
- Juvason
- Liquid Pred
- Lisacort
- Lodotra
- Lodtra
- Me-Korti
- Metacortandracin
- Meticorten
- Meticorten (Veterinary)
- NCI-C04897
- Nisona
- Nizon
- Novoprednisone
- NSC 10023
- Nurison
- Orasone
- Origen Prednisone
- Panafcort
- Panasol
- Paracort
- Parmenison
- Pehacort
- Predeltin
- Prednicen-M
- Prednicorm
- Prednicort
- Prednicot
- Prednidib
- Prednilonga
- Prednison
- Prednisona
- Prednisona [INN-Spanish]
- Prednisone
- Prednisone intensol
- Prednisonum
- Prednisonum [INN-Latin]
- Prednitone
- Prednizon
- Prednovister
- Pregna-1,4-diene-3,11,20-trione monohydrate, 17,21-dihydroxy-
- Presone
- Pronison
- Rayos
- Rectodelt
- Retrocortine
- Servisone
- SK-Prednisone
- Sone
- Sterapred
- Supercortil
- U 6020
- Ultracorten
- Ultracortene
- UNII-VB0R961HZT
- Winpred
- Wojtab
- Zenadrid
- Zenadrid (veterinary)
Systematic Names
- Prednisone
- Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-
Superlist Name
- Prednisone
Mixture Name
- Metrevet (Veterinary)
Registry Numbers
CAS Registry Number
- 53-03-2
FDA UNII
- VB0R961HZT
Other Registry Number
- 68-59-7
System Generated Number
- 0000053032
Structure Descriptors
InChI
InChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1InChIKey
XOFYZVNMUHMLCC-ZPOLXVRWSA-NSmiles
C[C@]12CC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | LDLo | oral | 400ug/kg (0.4mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Irish Journal of Medical Science. Vol. 155, Pg. 234, 1986. |
man | TDLo | oral | 857ug/kg (0.857mg/kg) | PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE | Neurology. Vol. 36, Pg. 729, 1986. |
mouse | LD50 | intramuscular | 600mg/kg (600mg/kg) | Cancer Research. Vol. 42, Pg. 122, 1982. | |
mouse | LD50 | intraperitoneal | 135mg/kg (135mg/kg) | National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, | |
mouse | LD50 | subcutaneous | 101mg/kg (101mg/kg) | National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, | |
women | TDLo | oral | 2400ug/kg/2D- (2.4mg/kg) | PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE | Neurology. Vol. 36, Pg. 729, 1986. |
women | TDLo | unreported | 113mg/kg (113mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" BLOOD: HEMORRHAGE | JAMA, Journal of the American Medical Association. Vol. 243, Pg. 1260, 1980. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 234 dec | deg C | EXP | |
log P (octanol-water) | 1.46 | (none) | EXP | |
Water Solubility | 312 | mg/L | 25 | EST |
Vapor Pressure | 5.09E-13 | mm Hg | 25 | EST |
Henry's Law Constant | 2.83E-10 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 6.79E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.