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Substance Name: Cortisone [INN:BAN]
RN: 53-06-5
UNII: V27W9254FZ
InChIKey: MFYSYFVPBJMHGN-ZPOLXVRWSA-N

Note

  • A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)

Molecular Formula

  • C21-H28-O5

Molecular Weight

  • 360.4472
 

Classification Codes

  • Anti-Inflammatory Agents
  • Human Data
  • Mutation Data
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Cortisone
  • Cortisone [INN:BAN]

MeSH Heading

  • Cortisone

Synonyms

  • 11-Dehydro-17-hydroxycorticosterone
  • 17-Hydroxy-11-dehydrocorticosterone
  • 17alpha,21-Dihydroxypregn-4-ene-3,11,20-trione
  • 17alpha-Hydroxy-11-dehydrocorticosterone
  • 4-Pregnene-17alpha,21-diol-3,11,20-trione
  • Adrenalex
  • AI3-52938
  • Andreson
  • Compound E
  • Cortisal
  • Cortisate
  • Cortisona
  • Cortisona [INN-Spanish]
  • Cortisone
  • Cortisonum
  • Cortisonum [INN-Latin]
  • Cortistal
  • Cortivite
  • Cortogen
  • Cortone
  • delta(sup4)-pregnene-17alpha,21-diol-3,11,20-trione
  • EINECS 200-162-4
  • KE
  • Kendall's compound E
  • NSC 9703
  • Pregn-4-en-17alpha,21-diol-3,11,20-trione
  • Reichstein Fa
  • Reichstein's substance FA
  • UNII-V27W9254FZ
  • Wintersteiner's compound F

Systematic Names

  • Cortisone
  • Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-

Registry Numbers

CAS Registry Number

  • 53-06-5

FDA UNII

  • V27W9254FZ

System Generated Number

  • 0000053065

Structure Descriptors

InChI

1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1

InChIKey

MFYSYFVPBJMHGN-ZPOLXVRWSA-N

Smiles

C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2C(=O)C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 222 deg C   EXP
log P (octanol-water) 1.47 (none)   EXP
Water Solubility 280 mg/L 25 EXP
Vapor Pressure 5.80E-13 mm Hg 25 EST
Henry's Law Constant 6.03E-10 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.10E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.