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Substance Name: Paramethasone [INN:BAN]
RN: 53-33-8
UNII: VFC6ZX3584
InChIKey: MKPDWECBUAZOHP-AFYJWTTESA-N

Note

  • A glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than HYDROCORTISONE with supplementary FLUDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p737)

Molecular Formula

  • C22-H29-F-O5

Molecular Weight

  • 392.464
 

Classification Codes

  • Adrenal Cortex Hormones
  • Anti-Inflammatory Agents
  • Glucocorticoids
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
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Names and Synonyms

Results Name

  • Paramethasone [INN:BAN]

Name of Substance

  • Paramethasone
  • Paramethasone [INN:BAN]

MeSH Heading

  • Paramethasone

Synonyms

  • 16alpha-Methyl-6alpha-fluoroprednisolone
  • 6alpha-Fluoro-16alpha-methylprednisolone
  • Alondra
  • Cassenne
  • Cortiden
  • CS 1483
  • Dillar
  • EINECS 200-169-2
  • Flumethone
  • HSDB 3376
  • Metilar
  • Parametasona
  • Parametasona [INN-Spanish]
  • Parametasone
  • Parametasone [DCIT]
  • Paramethasone
  • Paramethasonum
  • Paramethasonum [INN-Latin]
  • Paramezone
  • Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-16-methyl-, (6alpha,11beta,16alpha)-
  • Pregna-1,4-diene-3,20-dione, 6alpha-fluoro-11beta,17,21-trihydroxy-16alpha-methyl-
  • UNII-VFC6ZX3584

Systematic Names

  • Paramethasone
  • Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-16-methyl-, (6alpha,11beta,16alpha)-

Registry Numbers

CAS Registry Number

  • 53-33-8

FDA UNII

  • VFC6ZX3584

System Generated Number

  • 0000053338

Structure Descriptors

InChI

1S/C22H29FO5/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-20(15,2)19(13)17(26)9-21(14,3)22(11,28)18(27)10-24/h4-5,7,11,13-14,16-17,19,24,26,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20+,21+,22+/m1/s1

InChIKey

MKPDWECBUAZOHP-AFYJWTTESA-N

Smiles

C1[C@H]2[C@H]3[C@@]([C@](C(CO)=O)(O)[C@@H](C3)C)(C[C@@H]([C@@H]2[C@@]2(C(=CC(=O)C=C2)[C@H]1F)C)O)C

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 1.680 (none)   EST
Atmospheric OH Rate Constant 6.63E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.