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Substance Name: Methylprednisolone acetate [USP:JAN]
RN: 53-36-1
UNII: 43502P7F0P
InChIKey: PLBHSZGDDKCEHR-LFYFAGGJSA-N
Notes
- Methylprednisolone derivative that is used as an anti-inflammatory agent for the treatment of ALLERGY and ALLERGIC RHINITIS; ASTHMA; and BURSITIS; and for the treatment of ADRENAL INSUFFICIENCY.
- NCI: A synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone binds to and activates specific nuclear receptors, resulting in altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations. (NCI Thesaurus)
Molecular Formula
- C24-H32-O6
Molecular Weight
- 416.5108
Classification Codes
- Anti-Inflammatory Agents
- Drug / Therapeutic Agent
- Glucocorticoid
- Hormone
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Methylprednisolone acetate
- Methylprednisolone acetate [USP:JAN]
MeSH Heading
- Methylprednisolone acetate
Synonyms
- 11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate
- 6alpha-Methylprednisolone 21-acetate
- 6alpha-Methylprednisolone acetate
- D-Med
- depMedalone 40
- depMedalone 80
- Depo-Medrate
- Depo-Medrin
- Depo-medrol
- Depo-Medrone
- Depo-Methylprednisolone acetate
- Depomedrone
- Depometicort
- EINECS 200-171-3
- Lemod Depo
- M-Predrol
- Medrol
- Medrol acetate
- Medrol Enpak
- Mepred
- Methyl prednisolone acetate
- Methylprednisolone 21-acetate
- Methylprednisolone acetate
- NSC 48985
- Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-6-methyl-, (6-alpha,11-beta)-
- Solsolona
- Solsolona [inj.]
- U 8210
- Ubrason
- Ubrason [inj.]
- Unidrol
- UNII-43502P7F0P
- Urbason crystal suspension
Systematic Names
- Methylprednisolone 21-acetate
- Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl-, 21-acetate
- Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-6-methyl-, (6alpha,11beta)-
Mixture Name
- Neo-Medrol
Registry Numbers
CAS Registry Number
- 53-36-1
FDA UNII
- 43502P7F0P
System Generated Number
- 0000053361
Structure Descriptors
InChI
InChI=1S/C24H32O6/c1-13-9-16-17-6-8-24(29,20(28)12-30-14(2)25)23(17,4)11-19(27)21(16)22(3)7-5-15(26)10-18(13)22/h5,7,10,13,16-17,19,21,27,29H,6,8-9,11-12H2,1-4H3/t13-,16-,17-,19-,21+,22-,23-,24-/m0/s1InChIKey
PLBHSZGDDKCEHR-LFYFAGGJSA-NSmiles
C[C@H]1C[C@H]2[C@@H]3CC[C@](O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | > 1409mg/kg (1409mg/kg) | Drugs in Japan Vol. -, Pg. 1182, 1990. | |
mouse | LD50 | subcutaneous | 1320mg/kg (1320mg/kg) | GASTROINTESTINAL: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Journal of Toxicological Sciences. Vol. 10(Suppl, |
rat | LD50 | oral | > 10gm/kg (10000mg/kg) | Drugs in Japan Vol. -, Pg. 1182, 1990. | |
rat | LD50 | subcutaneous | 265mg/kg (265mg/kg) | GASTROINTESTINAL: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Journal of Toxicological Sciences. Vol. 10(Suppl, |