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Substance Name: Methylprednisolone acetate [USP:JAN]
RN: 53-36-1
UNII: 43502P7F0P
InChIKey: PLBHSZGDDKCEHR-LFYFAGGJSA-N

Notes

  • Methylprednisolone derivative that is used as an anti-inflammatory agent for the treatment of ALLERGY and ALLERGIC RHINITIS; ASTHMA; and BURSITIS; and for the treatment of ADRENAL INSUFFICIENCY.
  • NCI: A synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone binds to and activates specific nuclear receptors, resulting in altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations. (NCI Thesaurus)

Molecular Formula

  • C24-H32-O6

Molecular Weight

  • 416.5108
 

Classification Codes

  • Anti-Inflammatory Agents
  • Drug / Therapeutic Agent
  • Glucocorticoid
  • Hormone
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Methylprednisolone acetate
  • Methylprednisolone acetate [USP:JAN]

MeSH Heading

  • Methylprednisolone acetate

Synonyms

  • 11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate
  • 6alpha-Methylprednisolone 21-acetate
  • 6alpha-Methylprednisolone acetate
  • D-Med
  • depMedalone 40
  • depMedalone 80
  • Depo-Medrate
  • Depo-Medrin
  • Depo-medrol
  • Depo-Medrone
  • Depo-Methylprednisolone acetate
  • Depomedrone
  • Depometicort
  • EINECS 200-171-3
  • Lemod Depo
  • M-Predrol
  • Medrol
  • Medrol acetate
  • Medrol Enpak
  • Mepred
  • Methyl prednisolone acetate
  • Methylprednisolone 21-acetate
  • Methylprednisolone acetate
  • NSC 48985
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-6-methyl-, (6-alpha,11-beta)-
  • Solsolona
  • Solsolona [inj.]
  • U 8210
  • Ubrason
  • Ubrason [inj.]
  • Unidrol
  • UNII-43502P7F0P
  • Urbason crystal suspension

Systematic Names

  • Methylprednisolone 21-acetate
  • Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl-, 21-acetate (8CI)
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-6-methyl-, (6alpha,11beta)-

Mixture Name

  • Neo-Medrol

Registry Numbers

CAS Registry Number

  • 53-36-1

FDA UNII

  • 43502P7F0P

System Generated Number

  • 0000053361

Structure Descriptors

InChI

InChI=1S/C24H32O6/c1-13-9-16-17-6-8-24(29,20(28)12-30-14(2)25)23(17,4)11-19(27)21(16)22(3)7-5-15(26)10-18(13)22/h5,7,10,13,16-17,19,21,27,29H,6,8-9,11-12H2,1-4H3/t13-,16-,17-,19-,21+,22-,23-,24-/m0/s1

InChIKey

PLBHSZGDDKCEHR-LFYFAGGJSA-N

Smiles

C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(=O)COC(=O)C)[C@@]3(C)C[C@H](O)[C@@H]2[C@@]4(C)C=CC(=O)C=C14

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 1409mg/kg (1409mg/kg)   Drugs in Japan Vol. -, Pg. 1182, 1990.
mouse LD50 subcutaneous 1320mg/kg (1320mg/kg) GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Journal of Toxicological Sciences. Vol. 10(Suppl,
rat LD50 oral > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. -, Pg. 1182, 1990.
rat LD50 subcutaneous 265mg/kg (265mg/kg) GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Journal of Toxicological Sciences. Vol. 10(Suppl,