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Substance Name: Prasterone [USAN:INN]
RN: 53-43-0
UNII: 459AG36T1B
InChIKey: FMGSKLZLMKYGDP-USOAJAOKSA-N
Notes
- A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone ( DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated ( DEHYDROEPIANDROSTERONE SULFATE) before secretion.
- A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
Molecular Formula
- C19-H28-O2
Molecular Weight
- 288.4282
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Adjuvants, Immunologic
- Hormone
- Human Data
- Immunologic Factors
- Mutation Data
- Reproductive Effect
- Treatment of Moderate to Severe Dyspareunia (or Pain at Sexual Activity), a Symptom of Vulvovaginal Atrophy due to Menopause
- Tumor Data
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Names and Synonyms
Name of Substance
- Prasterone
- Prasterone [USAN:INN]
MeSH Heading
- Dehydroepiandrosterone
Synonyms
- (3-beta)-3-Hydroxyandrost-5-en-17-one
- 17-Chetovis
- 17-Hormoforin
- 3-beta-Hydroxy-5-androsten-17-one
- 3beta-Hydroxyandrost-5-en-17-one
- 4-08-00-00994 (Beilstein Handbook Reference)
- 5,6-Dehydroisoandrosterone
- 5,6-Dehydroisoandrostorone
- 5,6-Didehydroisoandrosterone
- 5-Dehydroepiandrosterone
- Andrestenol
- Androstenolone
- BRN 2058110
- Caswell No. 051F
- CCRIS 3277
- Dehydro-epi-androsterone
- Dehydroepiandrosterone
- Dehydroisoandrosterone
- DHEA
- Diandron
- Diandrone
- EC 200-175-5
- EINECS 200-175-5
- EM-760
- EPA Pesticide Chemical Code 126510
- Epiandrosterone, 5-dehydro-
- GL 701
- Gynodian
- Intrarosa
- NSC 9896
- Prasterona
- Prasterona [INN-Spanish]
- Prasterone
- Prasteronum
- Prasteronum [INN-Latin]
- Prestara
- Psicosterone
- Siscelar plus
- trans-Dehydroandrosterone
- UNII-459AG36T1B
Systematic Names
- 3beta-Hydroxyandrost-5-en-17-one
- Androst-5-en-17-one, 3-beta-hydroxy-
- Androst-5-en-17-one, 3-hydroxy-, (3-beta)-
- Androst-5-en-17-one, 3-hydroxy-, (3beta)-
- Androst-5-en-17-one, 3beta-hydroxy-
- Dehydroepiandrosterone
- Prasterone
Registry Numbers
CAS Registry Number
- 53-43-0
FDA UNII
- 459AG36T1B
Other Registry Numbers
- 105597-37-3
- 108673-53-6
- 9013-35-8
System Generated Number
- 0000053430
Structure Descriptors
InChI
InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1InChIKey
FMGSKLZLMKYGDP-USOAJAOKSA-NSmiles
C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | oral | 10mg/kg/2W-I (10mg/kg) | CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) | Annals of Internal Medicine. Vol. 129, Pg. 588, 1998. |
mouse | LD50 | oral | > 10gm/kg (10000mg/kg) | British UK Patent Application. Vol. #2208473, | |
mouse | LD50 | subcutaneous | 900mg/kg (900mg/kg) | British UK Patent Application. Vol. #2208473, | |
rat | LD50 | oral | > 10gm/kg (10000mg/kg) | British UK Patent Application. Vol. #2208473, | |
rat | LD50 | subcutaneous | 1gm/kg (1000mg/kg) | British UK Patent Application. Vol. #2208473, |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 140-141 | deg C | EXP | |
log P (octanol-water) | 3.23 | (none) | EXP | |
Water Solubility | 63.5 | mg/L | 25 | EXP |
Vapor Pressure | 2.23E-08 | mm Hg | 25 | EST |
Henry's Law Constant | 6.62E-09 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.27E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.