Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Promazine hydrochloride [USP]
RN: 53-60-1
UNII: U16EOR79U4
InChIKey: JIVSXRLRGOICGA-UHFFFAOYSA-N

Note

  • A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.

Molecular Formula

  • C17-H20-N2-S.Cl-H

Molecular Weight

  • 320.8859
 

Classification Codes

  • Antipsychotic
  • Drug / Therapeutic Agent
  • Human Data
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Promazine hydrochloride [USP]

Synonyms

  • 10-(3-(Dimethylamino)propyl)phenothiazine hydrochloride
  • 10-(3-(Dimethylamino)propyl)phenothiazine monohydrochloride
  • 10-(gamma-Dimethylamino-n-propyl)phenothiazine hydrochloride
  • 10-H-Phenothiazine-10-propanamine, N,N-dimethyl-, monohydrochloride
  • 10H-Phenothiazine-10-propanamine, N,N-dimethyl-, monohydrochloride
  • AI3-28022
  • Chlorowodorek promazyny
  • Chlorowodorek promazyny [Polish]
  • EINECS 200-179-7
  • N-(3-(Dimethylamino)propyl)phenothiazine hydrochloride
  • NSC 17468
  • Phenothiazine, 10-(3-(dimethylamino)propyl)-, hydrochloride
  • Promazine HCl
  • Promazine hydrochloride
  • Promazine monohydrochloride
  • RP 4560
  • Sparine
  • Starazin
  • Talofen
  • UNII-U16EOR79U4

Systematic Names

  • 10H-Phenothiazine-10-propanamine, N,N-dimethyl-, hydrochloride (1:1)
  • 10H-Phenothiazine-10-propanamine, N,N-dimethyl-, monohydrochloride
  • Phenothiazine, 10-(3-(dimethylamino)propyl)-, monohydrochloride
  • Promazine hydrochloride

Mixture Name

  • Ketaset Plus (Veterinary)

Registry Numbers

CAS Registry Number

  • 53-60-1

FDA UNII

  • U16EOR79U4

System Generated Number

  • 0000053601

Molecular Formulas

Molecular Formula

  • C17-H20-N2-S.Cl-H

Molecular Formula Fragments

  • C17-H20-N2-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C17H20N2S.ClH/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19;/h3-6,8-11H,7,12-13H2,1-2H3;1H

InChIKey

JIVSXRLRGOICGA-UHFFFAOYSA-N

Smiles

CN(C)CCCN1c2ccccc2Sc3c1cccc3.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intramuscular 4400ug/kg (4.4mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. -, 1965.
human TDLo oral 20mg/kg/D-I (20mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: TREMOR

BEHAVIORAL: ANTIPSYCHOTIC
Journal of Nervous and Mental Disease. Vol. 123, Pg. 553, 1956.
mouse LD50 intramuscular 28mg/kg (28mg/kg)   Annales Pharmaceutic. Vol. 13, Pg. 51, 1978.
mouse LD50 intravenous 38mg/kg (38mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 42, 1972.
mouse LD50 subcutaneous 300mg/kg (300mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 42, 1972.
rabbit LD50 intravenous 21mg/kg (21mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 42, 1972.
rat LD50 intravenous 29mg/kg (29mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 42, 1972.
rat LD50 oral 400mg/kg (400mg/kg)   Fortschritte der Arzneimittelforschung. Progress in Drug Research. Vol. 5, Pg. 269, 1963.
rat LDLo intraperitoneal 356mg/kg (356mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Pharmaceutical Sciences. Vol. 54, Pg. 295, 1965.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 181 dec deg C   EXP
log P (octanol-water) 2.94 (none)   EXP
Water Solubility 2.50E+05 mg/L   EXP
Vapor Pressure 7.89E-07 mm Hg 25 EST
Henry's Law Constant 4.98E-10 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.05E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.