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Substance Name: Sarcolysin [INN]
RN: 531-76-0
UNII: A960M0G5TP
InChIKey: SGDBTWWWUNNDEQ-UHFFFAOYSA-N

Molecular Formula

  • C13-H18-Cl2-N2-O2

Molecular Weight

  • 305.2032
 

Classification Codes

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 2B
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Names and Synonyms

Name of Substance

  • Sarcolysin [INN]

Synonyms

  • 4-(Bis(2-chloroethyl)amino)-DL-phenylalanine
  • AI3-25298
  • CB-3307
  • CCRIS 376
  • DL-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine
  • DL-Phenylalanine mustard
  • DL-Phenylalanine, 4-(bis(2-chloroethyl)amino)-
  • DL-Sarcolysin
  • DL-Sarcolysine
  • Merfalan
  • Merphalan
  • NCI-CO4944
  • NSC-14210
  • p-Di(2-chloroethyl)amino-DL-phenylalanine
  • p-Di-(2-chloraethyl)-amino-DL-phenyl-alanin
  • p-Di-(2-chloraethyl)-amino-DL-phenyl-alanin [German]
  • Phenylalanin-lost
  • Phenylalanin-lost [German]
  • Sarcoclorin
  • Sarcolisina
  • Sarcolisina [INN-Spanish]
  • Sarcolysin
  • Sarcolysine
  • Sarcolysine [INN-French]
  • Sarcolysinum
  • Sarcolysinum [INN-Latin]
  • UNII-A960M0G5TP

Systematic Names

  • Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, DL-
  • DL-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine
  • Merphalan
  • Phenylalanine, 4-(bis(2-chloroethyl)amino)-

Superlist Names

  • DL-Phenylalanine, 4-(bis(2-chloroethyl)amino)-
  • Merphalan

Registry Numbers

CAS Registry Number

  • 531-76-0

FDA UNII

  • A960M0G5TP

Other Registry Numbers

  • 46993-34-4
  • 51-87-6

System Generated Number

  • 0000531760

Structure Descriptors

InChI

1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)

InChIKey

SGDBTWWWUNNDEQ-UHFFFAOYSA-N

Smiles

NC(Cc1ccc(cc1)N(CCCl)CCCl)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 26mg/kg (26mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 634, 1966.
rat LD50 intracrebral 250ug/kg (0.25mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 18, Pg. 760, 1966.
rat LD50 intraperitoneal 18mg/kg (18mg/kg)   Doklady Biological Sciences Vol. 171, Pg. 801, 1966.
rat LD50 intravenous 25mg/kg (25mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 340, 1958.
rat LD50 oral 105mg/kg (105mg/kg)   Acta Unio Internationalis Contra Cancrum. Vol. 20, Pg. 144, 1964.
rat LD50 oral 105mg/kg (105mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Acta Unio Internationalis Contra Cancrum. Vol. 20, Pg. 144, 1964.