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Substance Name: Methocarbamol [USP:INN:BAN:JAN]
RN: 532-03-6
UNII: 125OD7737X
InChIKey: GNXFOGHNGIVQEH-UHFFFAOYSA-N
Note
- A centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1206)
Molecular Formula
- C11-H15-N-O5
Molecular Weight
- 241.2415
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Central Nervous System Agents
- Drug / Therapeutic Agent
- Muscle Relaxants, Central
- Neuromuscular Agents
- Peripheral Nervous System Agents
- Relaxant (Skeletal Muscle)
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Names and Synonyms
Name of Substance
- Methocarbamol
- Methocarbamol [USP:INN:BAN:JAN]
MeSH Heading
- Methocarbamol
Synonyms
- (+-)-3-(o-Methoxyphenoxy)-1,2-propanediol 1-carbamate
- 1,2-Propanediol, 3-(2-methoxyphenoxy)-, 1-carbamate
- 1,2-Propanediol, 3-(o-methoxyphenoxy)-, 1-carbamate
- 2-Hydroxy-3-(o-methoxyphenoxy)propyl 1-carbamate
- 3-(2-Methoxyphenoxy)-1-glyceryl carbamate
- 3-(o-Methoxyphenoxy)-1,2-propanediol 1-carbamate
- 3-(o-Methoxyphenoxy)-2-hydroxypropyl carbamate
- 4-06-00-05577 (Beilstein Handbook Reference)
- AHR 85
- Avetil
- BRN 1884446
- Carbamic acid, 2-hydroxy-3-(o-methoxyphenoxy)propyl ester
- Delaxin
- EINECS 208-524-3
- Etroflex
- Forbaxin
- Glycerylguaiacolate carbamate
- Glycerylguajacol-carbamat
- Guaiacol glyceryl ether carbamate
- Guaiphenesine carbamate
- Guiacol-gliceriletere monocarbammato
- HSDB 3122
- Lumirelax
- Methocal
- Methocarbamol
- Methocarbamolum
- Methocarbamolum [INN-Latin]
- Metocarbamol
- Metocarbamol [INN-Spanish]
- Metocarbamolo
- Metocarbamolo [DCIT]
- Metofenia
- Metofenina
- Miolaxene
- Miorilas
- Miowas
- Myolaxene
- Neuraxin
- NSC 170960
- Parabaxin
- Perilax
- Reflexyn
- Relax
- Relestrid
- Robaxin
- Robaxin-750
- Robinax
- Romethocarb
- Surquetil
- Tresortil
- UNII-125OD7737X
Systematic Names
- 1,2-Propanediol, 3-(2-methoxyphenoxy)-, 1-carbamate
- 1,2-Propanediol, 3-(o-methoxyphenoxy)-, 1-carbamate
- Methocarbamol
Mixture Names
- Robaxisal
- Robaxisol
Registry Numbers
CAS Registry Number
- 532-03-6
FDA UNII
- 125OD7737X
Other Registry Number
- 145308-03-8
System Generated Number
- 0000532036
Structure Descriptors
InChI
InChI=1S/C11H15NO5/c1-15-9-4-2-3-5-10(9)16-6-8(13)7-17-11(12)14/h2-5,8,13H,6-7H2,1H3,(H2,12,14)InChIKey
GNXFOGHNGIVQEH-UHFFFAOYSA-NSmiles
COc1ccccc1OCC(O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | oral | 2gm/kg (2000mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 398, 1972. | |
hamster | LD50 | intraperitoneal | 1050mg/kg (1050mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ATAXIA BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 75, 1960. |
hamster | LD50 | oral | 1410mg/kg (1410mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE WEAKNESS | Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 75, 1960. |
mouse | LD50 | intraperitoneal | 950mg/kg (950mg/kg) | Toxicology and Applied Pharmacology. Vol. 2, Pg. 264, 1960. | |
mouse | LD50 | intravenous | 774mg/kg (774mg/kg) | Drugs in Japan Vol. 6, Pg. 836, 1982. | |
mouse | LD50 | oral | 812mg/kg (812mg/kg) | Drugs in Japan Vol. 6, Pg. 836, 1982. | |
mouse | LD50 | subcutaneous | 780mg/kg (780mg/kg) | BEHAVIORAL: ANTICONVULSANT | Acta Pharmacologica et Toxicologica. Vol. 19, Pg. 247, 1962. |
rabbit | LD50 | intravenous | 680mg/kg (680mg/kg) | BEHAVIORAL: REGIDITY SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | International Journal of Neuropharmacology. Vol. 5, Pg. 305, 1966. |
rat | LD50 | intraperitoneal | 815mg/kg (815mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 242, 1967. |
rat | LD50 | oral | 1320mg/kg (1320mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE WEAKNESS | Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 75, 1960. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 93 | deg C | EXP | |
log P (octanol-water) | 0.61 | (none) | EXP | |
Water Solubility | 7200 | mg/L | 25 | EXP |
Vapor Pressure | 3.41E-07 | mm Hg | 25 | EST |
Henry's Law Constant | 6.53E-16 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 4.51E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.