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Substance Name: Mefloquine [USAN:INN:BAN]
RN: 53230-10-7
UNII: TML814419R
InChIKey: XEEQGYMUWCZPDN-DOMZBBRYSA-N

Note

  • A phospholipid-interacting antimalarial drug (ANTIMALARIALS). It is very effective against PLASMODIUM FALCIPARUM with very few side effects.

Molecular Formula

  • C17-H16-F6-N2-O

Molecular Weight

  • 378.3144
 

Classification Codes

  • Anti-Infective Agents
  • Antimalarial
  • Antimalarials
  • Antiparasitic Agents
  • Antiprotozoal Agents
  • Drug / Therapeutic Agent
  • Human Data

Names and Synonyms

Name of Substance

  • Mefloquine
  • Mefloquine [USAN:INN:BAN]

MeSH Heading

  • Mefloquine

Synonyms

  • (DL-erythro-alpha-2-Piperidyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol
  • HSDB 6853
  • Lariam
  • Mefloquin
  • Mefloquina
  • Mefloquina [INN-Spanish]
  • Mefloquine
  • Mefloquinum
  • Mefloquinum [INN-Latin]
  • Racemic mefloquine
  • Ro 21-5998
  • Ro 215998
  • UNII-TML814419R
  • WR 142,490
  • WR 142490

Systematic Names

  • 4-Quinolinemethanol, alpha-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-, (alphaS)-rel-
  • 4-Quinolinemethanol, alpha-2-piperidinyl-2,8-bis(trifluoromethyl)-, (R*,S*)-(+-)-

Registry Numbers

CAS Registry Number

  • 53230-10-7

FDA UNII

  • TML814419R

Other Registry Number

  • 68682-27-9

System Generated Number

  • 0053230107

Structure Descriptors

InChI

1S/C17H16F6N2O/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11/h3-5,8,12,15,24,26H,1-2,6-7H2/t12-,15+/m1/s1

InChIKey

XEEQGYMUWCZPDN-DOMZBBRYSA-N

Smiles

c1cc2c(cc(nc2c(c1)C(F)(F)F)C(F)(F)F)[C@@H]([C@H]3CCCCN3)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
women TDLo oral 25mg/kg/5W-I (25mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

MUSCULOSKELETAL: JOINTS
Annals of Internal Medicine. Vol. 123, Pg. 894, 1995.