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Substance Name: Diethylcarbamazine hydrochloride
RN: 5348-97-0
InChIKey: WCJHPDVYERQRGZ-UHFFFAOYSA-N

Note

  • An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.

Molecular Formula

  • C10-H21-N3-O.Cl-H

Molecular Weight

  • 235.7568
 

Classification Codes

  • Anthelmintics
  • Anti-Infective Agents
  • Antinematodal Agents
  • Antiparasitic Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Filaricides
  • Lipoxygenase Inhibitors
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Names and Synonyms

Results Name

  • Diethylcarbamazine hydrochloride

Synonyms

  • 1-Diethylcarbamyl-4-methylpiperazine hydrochloride
  • 1-Piperazinecarboxamide, N,N-diethyl-4-methyl-, hydrochloride
  • Diethylcarbamazine HCl
  • Diethylcarbamazine hydrochloride
  • EINECS 226-309-2
  • NSC 1364

Systematic Names

  • 1-Piperazinecarboxamide, N,N-diethyl-4-methyl-, hydrochloride
  • 1-Piperazinecarboxamide, N,N-diethyl-4-methyl-, monohydrochloride
  • N,N-Diethyl-4-methylpiperazine-1-carboxamide monohydrochloride

Registry Numbers

CAS Registry Number

  • 5348-97-0

Related Registry Number

  • 90-89-1 (Parent)

System Generated Number

  • 0005348970

Molecular Formulas

Molecular Formula

  • C10-H21-N3-O.Cl-H

Molecular Formula Fragments

  • C10-H21-N3-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C10H21N3O.ClH/c1-4-12(5-2)10(14)13-8-6-11(3)7-9-13;/h4-9H2,1-3H3;1H

InChIKey

WCJHPDVYERQRGZ-UHFFFAOYSA-N

Smiles

Cl.CCN(CC)C(=O)N1CCN(C)CC1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 248mg/kg (248mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Annals of the New York Academy of Sciences. Vol. 50, Pg. 141, 1948.
mouse LD50 intravenous 82mg/kg (82mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Annals of the New York Academy of Sciences. Vol. 50, Pg. 141, 1948.
mouse LD50 oral 660mg/kg (660mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Annals of the New York Academy of Sciences. Vol. 50, Pg. 141, 1948.
rat LD50 intraperitoneal 285mg/kg (285mg/kg)   Compilation of LD50 Values of New Drugs.
rat LD50 intravenous 150mg/kg (150mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Annals of the New York Academy of Sciences. Vol. 50, Pg. 141, 1948.
rat LD50 oral 1380mg/kg (1380mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Annals of the New York Academy of Sciences. Vol. 50, Pg. 141, 1948.