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Substance Name: beta-Acetyldigoxin
RN: 5355-48-6
UNII: P7K44M64CW
InChIKey: NREAGDHHMSOWKZ-DXJNJSHLSA-N

Notes

  • Alpha- or beta-acetyl derivatives of DIGOXIN or lanatoside C from Digitalis lanata. They are better absorbed and longer acting than digoxin and are used in congestive heart failure.
  • Alpha- or beta-acetyl derivatives of DIGOXIN or lanatoside C from Digitalis lanata. They are better absorbed and longer acting than digoxin and are used in congestive heart failure./Acetyldigoxins/

Molecular Formula

  • C43-H66-O15

Molecular Weight

  • 822.9794
 

Classification Codes

  • Anti-Arrhythmia Agents
  • Cardiotonic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Human Data
  • Protective Agents
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Names and Synonyms

Name of Substance

  • beta-Acetyldigoxin

MeSH Heading

  • Acetyldigoxins

Synonyms

  • 16'-Acetyldigoxin
  • 4'''-Acetyldigoxin
  • Acetyl-digoxin-beta
  • Cardioreg
  • Cor-Puren
  • Digorid B
  • Digotab
  • Digoxigenin + zuckerkette wie bei acetyl-digitoxin-alpha
  • Digoxigenin + zuckerkette wie bei acetyl-digitoxin-alpha [German]
  • Digoxin Didier
  • EINECS 226-337-5
  • Kardiamed
  • Longdigox
  • Novodigal
  • Stillacor
  • UNII-P7K44M64CW

Systematic Names

  • Card-20(22)-enolide, 3-((O-4-O-acetyl-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1.4)-O-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1.4)-2,6-dideoxy-beta-d-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3beta,5beta,12beta)-
  • Digoxin, 4'''-acetate (8CI)
  • Digoxin, acetate, beta-

Registry Numbers

CAS Registry Number

  • 5355-48-6

FDA UNII

  • P7K44M64CW

System Generated Number

  • 0005355486

Structure Descriptors

InChI

1S/C43H66O15/c1-20-38(55-23(4)44)30(45)17-36(53-20)57-40-22(3)54-37(18-32(40)47)58-39-21(2)52-35(16-31(39)46)56-26-9-11-41(5)25(14-26)7-8-28-29(41)15-33(48)42(6)27(10-12-43(28,42)50)24-13-34(49)51-19-24/h13,20-22,25-33,35-40,45-48,50H,7-12,14-19H2,1-6H3/t20-,21-,22-,25-,26+,27-,28-,29+,30+,31+,32+,33-,35+,36+,37+,38-,39-,40-,41+,42+,43+/m1/s1

InChIKey

NREAGDHHMSOWKZ-DXJNJSHLSA-N

Smiles

C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2CC[C@]3([C@@H](C2)CC[C@@H]4[C@@H]3C[C@H]([C@]5([C@@]4(CC[C@@H]5C6=CC(=O)OC6)O)C)O)C)O)O[C@H]7C[C@@H]([C@@H]([C@H](O7)C)O[C@H]8C[C@@H]([C@@H]([C@H](O8)C)OC(=O)C)O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intraduodenal 413ug/kg (0.413mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 687, 1969.
cat LDLo intravenous 285ug/kg (0.285mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 687, 1969.
child TDLo oral 372ug/kg (0.372mg/kg) CARDIAC: PULSE RATE

CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE
Intensive Care Medicine. Vol. 4, Pg. 199, 1978.
dog LD50 oral 422ug/kg (0.422mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

GASTROINTESTINAL: NAUSEA OR VOMITING
Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1914, 1974.
guinea pig LD50 oral 2400ug/kg (2.4mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 481, 1965.
guinea pig LDLo intravenous 1380ug/kg (1.38mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 483, 1965.
pigeon LDLo intravenous 387ug/kg (0.387mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 225, 1971.