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Substance Name: Acoin
RN: 537-05-3

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C23-H25-N3-O3.Cl-H

Molecular Weight

  • 427.929
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Names and Synonyms

Results Name

  • Acoin


  • 2-(4-Ethoxyphenyl)-1,3-bis(4-methoxyphenyl)guanidine hydrochloride
  • Acoin
  • Acoin hydrochloride
  • Acoine
  • Akoin hydrochlorid
  • Akoin hydrochlorid [German]
  • alpha,gamma-Di-p-anisyl-beta-(ethoxyphenyl)guanidine hydrochloride
  • Dianisyl-monophenethylguanidine hydrochloride
  • Diparaanisyl-monophenethyl-guanidin-hydrochlorid
  • Diparaanisyl-monophenethyl-guanidin-hydrochlorid [German]
  • Guanicaine
  • N,N'-Bis(4-methoxyphenyl)-N''-(4-ethoxyphenyl)guanidine hydrochloride
  • Phenodianisyl
  • Phenodianisyl hydrochloride

Systematic Names

  • Guanidine, 2-(4-ethoxyphenyl)-1,3-bis(4-methoxyphenyl)-, hydrochloride (9CI)
  • Guanidine, 2-(p-ethoxyphenyl)-1,3-bis(p-methoxyphenyl)-, hydrochloride

Registry Numbers

CAS Registry Number

  • 537-05-3

System Generated Number

  • 0000537053

Molecular Formulas

Molecular Formula

  • C23-H25-N3-O3.Cl-H

Molecular Formula Fragments

  • C23-H25-N3-O3
  • Cl-H

Structure Descriptors








Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo oral 75mg/kg (75mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1291, 1935.
guinea pig LDLo subcutaneous 150mg/kg (150mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1291, 1935.
mouse LDLo intravenous 53mg/kg (53mg/kg) BEHAVIORAL: GENERAL ANESTHETIC "Vergleichend-pharmakologische Untersuchungen ueber die haemolytische Wirkung und die Toxizitat der Lokalanaesthetika, Dissertation," Walther, M., Pharmakologischen Instit Martin Luther-Universitat Halle-Wittenburg, Ger. Dem. Rep., 1936Vol. -, Pg. -, 1936.
mouse LDLo subcutaneous 300mg/kg (300mg/kg) BEHAVIORAL: EXCITEMENT "Pharmakologische Prufung von Analgetika, Dissertation," Herrlen, G., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1933Vol. -, Pg. -, 1933.
rabbit LDLo subcutaneous 150mg/kg (150mg/kg)   Merck Index. Vol. 10, Pg. 1043, 1983.