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Substance Name: Leuprorelin [INN:BAN]
RN: 53714-56-0
UNII: EFY6W0M8TG
InChIKey: GFIJNRVAKGFPGQ-LIJARHBVSA-N

Note

  • A potent synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE that regulates the synthesis and release of pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE.

Molecular Formula

  • C59-H84-N16-O12

Molecular Weight

  • 1209.4126
 

Classification Codes

  • Antineoplastic Agents
  • Antineoplastic Agents, Hormonal
  • Fertility Agents
  • Fertility Agents, Female
  • Hormone
  • Human Data
  • Reproductive Control Agents
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Leuprolide
  • Leuprorelin [INN:BAN]

MeSH Heading

  • Leuprolide

Synonyms

  • (D-Leu(sup 6),des-gly-NH2(sup 10),pro-ethylamide(sup 9))-GNRH
  • (D-Leu(sup 6),des-gly-NH2(sup 10),pro-ethylamide(sup 9))-gonadotropin-releasing hormone
  • (D-Leu(sup 6),des-gly-NH2(sup 10),pro-ethylamide(sup 9))-LHRH
  • A-43818
  • CCRIS 8462
  • Eligard
  • HSDB 6518
  • Leuprolide
  • Leuprorelin
  • Leuprorelina
  • Leuprorelina [INN-Spanish]
  • Leuproreline
  • Leuproreline [INN-French]
  • Leuprorelinum
  • Leuprorelinum [INN-Latin]
  • NSC 377526
  • UNII-EFY6W0M8TG

Systematic Names

  • Luteinizing hormone-releasing factor (pig), 6-D-leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide-
  • Luteinizing hormone-releasing hormone (pig), 6-D-leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide-

Registry Numbers

CAS Registry Number

  • 53714-56-0

FDA UNII

  • EFY6W0M8TG

Related Registry Number

  • 74381-53-6 (monoacetate)

System Generated Number

  • 0053714560

Structure Descriptors

InChI

1S/C59H84N16O12/c1-6-63-57(86)48-14-10-22-75(48)58(87)41(13-9-21-64-59(60)61)68-51(80)42(23-32(2)3)69-52(81)43(24-33(4)5)70-53(82)44(25-34-15-17-37(77)18-16-34)71-56(85)47(30-76)74-54(83)45(26-35-28-65-39-12-8-7-11-38(35)39)72-55(84)46(27-36-29-62-31-66-36)73-50(79)40-19-20-49(78)67-40/h7-8,11-12,15-18,28-29,31-33,40-48,65,76-77H,6,9-10,13-14,19-27,30H2,1-5H3,(H,62,66)(H,63,86)(H,67,78)(H,68,80)(H,69,81)(H,70,82)(H,71,85)(H,72,84)(H,73,79)(H,74,83)(H4,60,61,64)/t40-,41-,42-,43+,44-,45-,46-,47-,48-/m0/s1

InChIKey

GFIJNRVAKGFPGQ-LIJARHBVSA-N

Smiles

CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc3c[nH]c4c3cccc4)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@@H]6CCC(=O)N6