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Substance Name: Cytochalasin H
RN: 53760-19-3
InChIKey: NAEWXXDGBKTIMN-PQOXNSRFSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
  • Natural Product

Molecular Formula

  • C30-H39-N-O5

Molecular Weight

  • 493.64
 
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Names and Synonyms

Name of Substance

  • Cytochalasin H

Synonyms

  • 21-Acetoxy-7,18-dihydroxy-16,18-dimethyl-10-phenyl-(11)cytochalasa-6(12),13,19-triene-1-one
  • Cytochalasin-H
  • Kodocytochalasin-1
  • NSC 305222
  • Paspalin
  • Paspalin P I

Systematic Name

  • (11)Cytochalasa-6(12),13,19-trien-1-one, 21-(acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18S,19E,21R)-

Registry Numbers

CAS Registry Number

  • 53760-19-3

System Generated Number

  • 0053760193

Structure Descriptors

InChI

1S/C30H39NO5/c1-18-10-9-13-23-27(33)20(3)19(2)26-24(16-22-11-7-6-8-12-22)31-28(34)30(23,26)25(36-21(4)32)14-15-29(5,35)17-18/h6-9,11-15,18-19,23-27,33,35H,3,10,16-17H2,1-2,4-5H3,(H,31,34)/b13-9+,15-14+/t18-,19+,23-,24-,25+,26-,27+,29+,30?/m0/s1

InChIKey

NAEWXXDGBKTIMN-PQOXNSRFSA-N

Smiles

C1([C@@]23[C@H]([C@@H](Cc4ccccc4)N1)[C@@H](C(=C)[C@H]([C@@H]2C=CC[C@H](C)C[C@](C=C[C@H]3OC(C)=O)(C)O)O)C)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LD50 oral 12500ug/kg (12.5mg/kg)   Canadian Journal of Microbiology. Vol. 22, Pg. 1137, 1976.
mammal (species unspecified) LD50 intraperitoneal 2341ug/kg (2.341mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Indian Drugs. Vol. 15, Pg. 76, 1978.
mouse LD50 intravenous 2mg/kg (2mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 2, Pg. 439, 1980.
mouse LDLo unreported 2mg/kg (2mg/kg)   Japanese Journal of Experimental Medicine. Vol. 48, Pg. 105, 1978.