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Substance Name: Oxophenarsine hydrochloride [USP]
RN: 538-03-4
UNII: OG8JNR786U
InChIKey: JRIGVWDKYXCHMG-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data

Molecular Formula

  • C6-H6-As-N-O2.Cl-H

Molecular Weight

  • 235.501
 
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Names and Synonyms

Name of Substance

  • Oxophenarsine hydrochloride [USP]

Synonyms

  • 2-Amino-4-arsenosophenol hydrochloride
  • 3-Amino-4-hydroxy-phenarsine hydrochloride
  • 3-Amino-4-hydroxyphenyl arsinoxide hydrochloride
  • 3-Amino-4-hydroxyphenylarsine oxide hydrochloride
  • AI3-04455
  • Arseno 39
  • Arsenosan
  • Arsenoxide
  • Arsphenoxide
  • Ehrlich 5
  • EINECS 208-682-3
  • Fontarsan
  • Mapharsal
  • Mapharsen
  • Mapharside
  • Metarsen
  • NSC 3087
  • Oxiarsolan
  • Oxophenarsine HCl
  • Oxophenarsine hydrochloride
  • Oxophenarsini hydrochloridum
  • Treparsen
  • UNII-OG8JNR786U

Systematic Names

  • 2-Amino-4-arsenosophenol hydrochloride
  • Oxophenarsine hydrochloride
  • Phenol, 2-amino-4-arsenoso-, hydrochloride
  • Phenol, 2-amino-4-arsenoso-, monohydrochloride (9CI)

Registry Numbers

CAS Registry Number

  • 538-03-4

FDA UNII

  • OG8JNR786U

Related Registry Number

  • 306-12-7 (Parent)

System Generated Number

  • 0000538034

Molecular Formulas

Molecular Formula

  • C6-H6-As-N-O2.Cl-H

Molecular Formula Fragments

  • C6-H6-As-N-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C6H6AsNO2.ClH/c8-5-3-4(7-10)1-2-6(5)9;/h1-3,9H,8H2;1H

InChIKey

JRIGVWDKYXCHMG-UHFFFAOYSA-N

Smiles

c1(cc(c(O)cc1)N)[As]=O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 7mg/kg (7mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Journal of Pharmacology and Experimental Therapeutics. Vol. 50, Pg. 198, 1934.
dog LDLo intravenous 12mg/kg (12mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: OTHER CHANGES
Journal of Pharmacology and Experimental Therapeutics. Vol. 50, Pg. 198, 1934.
human TDLo intravenous 400ug/kg (0.4mg/kg) BEHAVIORAL: COMA

BRAIN AND COVERINGS: "CHANGES IN CIRCULATION (HEMORRHAGE, THROMBOSIS, ETC.)"

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
American Journal of Syphilis, Gonorrhea and Venereal Diseases. Vol. 28, Pg. 218, 1944.
mouse LD50 intraperitoneal 31mg/kg (31mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 81, Pg. 284, 1944.
mouse LD50 intravenous 20mg/kg (20mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 81, Pg. 284, 1944.
mouse LD50 oral 110ug/kg (0.11mg/kg)   Compilation of LD50 Values of New Drugs.
mouse LD50 subcutaneous 25mg/kg (25mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 81, Pg. 284, 1944.
rabbit LD50 intravenous 13mg/kg (13mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 81, Pg. 142, 1944.
rat LD50 intravenous 18500ug/kg (18.5mg/kg)   Journal of the American Chemical Society. Vol. 70, Pg. 1762, 1948.
rat LDLo oral 500mg/kg (500mg/kg)   National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 12, 1953.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -2.640 (none)   EST
Atmospheric OH Rate Constant 7.27E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.