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Substance Name: Ambazone [INN:BAN:DCF]
RN: 539-21-9
UNII: BYK4592A3Q
InChIKey: MLMFUKWWZIZRHX-UWRPRBHNSA-N

Classification Codes

  • Bacteriostatic
  • Drug / Therapeutic Agent
  • Mutation Data

Molecular Formula

  • C8-H11-N7-S

Molecular Weight

  • 237.29
 
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Names and Synonyms

Name of Substance

  • 1,4-Benzoquinone guanylhydrazone thiosemicarbazone
  • Ambazone [INN:BAN:DCF]

Synonyms

  • ((4-Oxo-2,5-cyclohexadien-1-ylidene)amino)guanidine thiosemicarbazone
  • 1-Amidinohydrazono-4-thiosemicarbazono-2,5-cyclohexadiene
  • 4-Amidinohydrazono-2,5-cyclohexadien-1-on-thiosemicarbazon
  • Ambazon
  • Ambazona
  • Ambazona [INN-Spanish]
  • Ambazone
  • Ambazonum
  • Ambazonum [INN-Latin]
  • Anginon
  • Benzoquinone guanylhydrazone thiosemicarbazone
  • CCRIS 1926
  • DC 0572
  • EINECS 208-713-0
  • Faringosept
  • Guanothiazon
  • Hydrazinecarbothioamide, 2-(4-((aminoiminomethyl)hydrazono)-2,5-cyclohexadien-1-ylidene)-
  • Inversal
  • Iversal
  • Ivertol
  • p-Benzoquinone amidinohydrazone thiosemicarbazone
  • Primal
  • Promassol
  • UNII-BYK4592A3Q

Systematic Names

  • Ambazone
  • Guanidine, ((4-oxo-2,5-cyclohexadien-1-ylidene)amino)-, thiosemicarbazone
  • Hydrazinecarbothioamide, 2-(4-((aminoiminomethyl)hydrazono)-2,5-cyclohexadien-1-ylidene)-

Registry Numbers

CAS Registry Number

  • 539-21-9

FDA UNII

  • BYK4592A3Q

System Generated Number

  • 0000539219

Structure Descriptors

InChI

1S/C8H11N7S/c9-7(10)14-12-5-1-3-6(4-2-5)13-15-8(11)16/h1-4H,(H4,9,10,14)(H3,11,15,16)/b12-5-,13-6+

InChIKey

MLMFUKWWZIZRHX-UWRPRBHNSA-N

Smiles

C1=C\C(=N\NC(=N)N)C=C\C1=N\NC(=S)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 80mg/kg (80mg/kg)   Drugs in Japan Vol. 6, Pg. 57, 1982.
mouse LD50 intraperitoneal 750mg/kg (750mg/kg)   Archives of Toxicology, Supplement. Vol. 11, Pg. P6, 1987.
mouse LD50 oral 1gm/kg (1000mg/kg)   Drugs in Japan Vol. 6, Pg. 57, 1982.
rat LD50 intraperitoneal 200mg/kg (200mg/kg)   Archives of Toxicology, Supplement. Vol. 11, Pg. P6, 1987.
rat LD50 oral 750mg/kg (750mg/kg)   Drugs in Japan Vol. 6, Pg. 57, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 1.23 (none)   EXP
Water Solubility 2470 mg/L 25 EST
Vapor Pressure 1.03E-07 mm Hg 25 EST
Henry's Law Constant 5.04E-16 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.81E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.