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Substance Name: Pentostatin [USAN:INN:BAN:JAN]
RN: 53910-25-1
UNII: 395575MZO7
InChIKey: FPVKHBSQESCIEP-JQCXWYLXSA-N
Note
- A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
Molecular Formula
- C11-H16-N4-O4
Molecular Weight
- 268.2714
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Adenosine Deaminase Inhibitors
- Antineoplastic Agents
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Human Data
- Potentiator
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Pentostatin
- Pentostatin [USAN:INN:BAN:JAN]
MeSH Heading
- Pentostatin
Synonyms
- (R)-2'-Deoxycoformycin
- (R)-3-(2-Deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo(4,5-d)(1,3)diazepin-8-ol
- (R)-Deoxycoformycin
- 2'-DCF
- 2'-Deoxycoformycin
- 8R-2'-Deoxycoformycin
- BRN 1223097
- CI-825
- CL 67310465
- Co-V
- Co-vidarabine
- dCF
- Deaminase inhibitor (PD)
- Deaminase, inhibitor for adenosine arabinoside
- Deoxycoformycin
- HSDB 6547
- Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydro-, (R)-
- Nipent
- NSC 218321
- NSC-218321
- PD 81565
- PD-ADI
- Pentostatin
- Pentostatina
- Pentostatina [INN-Spanish]
- Pentostatine
- Pentostatine [INN-French]
- Pentostatinum
- Pentostatinum [INN-Latin]
- UNII-395575MZO7
- Vidarbine
- Vira A deaminase inhibitor
- YK-176
Systematic Names
- Co-vidarabine
- Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydro-, (R)-
Superlist Name
- Pentostatin
Registry Numbers
CAS Registry Number
- 53910-25-1
FDA UNII
- 395575MZO7
Other Registry Numbers
- 59979-24-7
- 63677-95-2
- 69196-00-5
- 70865-77-9
System Generated Number
- 0053910251
Structure Descriptors
InChI
InChI=1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1InChIKey
FPVKHBSQESCIEP-JQCXWYLXSA-NSmiles
OC[C@H]1O[C@H](C[C@@H]1O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LDLo | intravenous | 360mg/kg (360mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 7888, 1990. |
mouse | LD50 | intravenous | 122mg/kg (122mg/kg) | National Technical Information Service. Vol. PB84-211424, | |
mouse | LD50 | intravenous | 122mg/kg (122mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | National Technical Information Service. Vol. PB84-211424, |
mouse | LD50 | oral | 227mg/kg (227mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 7888, 1990. | |
mouse | LD50 | oral | 227mg/kg (227mg/kg) | KIDNEY, URETER, AND BLADDER: HEMATURIA | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 7888, 1990. |
women | LDLo | unreported | 390mg/kg/3D-I (390mg/kg) | BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" BLOOD: THROMBOCYTOPENIA | Internal Medicine. Vol. 34, Pg. 593, 1995. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 220 | deg C | EXP | |
pKa Dissociation Constant | 5.2 | (none) | EXP | |
log P (octanol-water) | -2.540 | (none) | EST | |
Atmospheric OH Rate Constant | 1.80E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.