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Substance Name: Protirelin tartrate
RN: 53935-32-3
UNII: SYW8T997EQ
InChIKey: KPUAAIHTPMAPLR-GJAJEHNISA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C16-H22-N6-O4.C4-H6-O4

Molecular Weight

  • 512.4732
 
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Names and Synonyms

Results Name

  • Protirelin tartrate

Name of Substance

  • Protirelin tartrate [JAN]

Synonyms

  • L-Pyroglutamyl-L-histidyl-L-prolineamide-L-tartrate
  • Protirelin tartrate
  • TRH-T
  • UNII-SYW8T997EQ

Systematic Name

  • L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-, tartrate

Registry Numbers

CAS Registry Number

  • 53935-32-3

FDA UNII

  • SYW8T997EQ

Related Registry Number

  • 24305-27-9 (Parent)

System Generated Number

  • 0053935323

Molecular Formulas

Molecular Formula

  • C16-H22-N6-O4.C4-H6-O4

Molecular Formula Fragments

  • C16-H22-N6-O4
  • C4-H6-O4
  • COMPONENT

Structure Descriptors

InChI

1S/C16H22N6O4.C4H6O6/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10;5-1(3(7)8)2(6)4(9)10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25);1-2,5-6H,(H,7,8)(H,9,10)/t10-,11-,12-;1-,2-/m01/s1

InChIKey

KPUAAIHTPMAPLR-GJAJEHNISA-N

Smiles

NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]3CCC(=O)N3.O[C@H]([C@@H](O)C(=O)O)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 3300mg/kg (3300mg/kg)   Drugs in Japan Vol. 6, Pg. 727, 1982.
mouse LD50 intraperitoneal 3980mg/kg (3980mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: TREMOR

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 36, Pg. 22A, 1977.
mouse LD50 intravenous 520mg/kg (520mg/kg)   Drugs in Japan Vol. 6, Pg. 727, 1982.
mouse LD50 oral 16gm/kg (16000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: TREMOR
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 36, Pg. 22A, 1977.
mouse LD50 subcutaneous 5400mg/kg (5400mg/kg)   Drugs in Japan Vol. 6, Pg. 727, 1982.
rat LD50 intramuscular 2900mg/kg (2900mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: TREMOR
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 36, Pg. 22A, 1977.
rat LD50 intraperitoneal 2700mg/kg (2700mg/kg) BEHAVIORAL: TREMOR

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 36, Pg. 22A, 1977.
rat LD50 intravenous 580mg/kg (580mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: TREMOR

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 36, Pg. 22A, 1977.
rat LD50 oral 18gm/kg (18000mg/kg) BEHAVIORAL: TREMOR

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 36, Pg. 22A, 1977.
rat LD50 subcutaneous 6600mg/kg (6600mg/kg)   Drugs in Japan Vol. 6, Pg. 727, 1982.