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Substance Name: Cefaclor [INN]
RN: 53994-73-3
UNII: 3Z6FS3IK0K
InChIKey: QYIYFLOTGYLRGG-GPCCPHFNSA-N

Note

  • Semisynthetic, broad-spectrum antibiotic derivative of CEPHALEXIN.

Molecular Formula

  • C15-H14-Cl-N3-O4-S

Molecular Weight

  • 367.8116
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect

Names and Synonyms

Results Name

  • Cefaclor [INN]

Name of Substance

  • Cefaclor anhydrous
  • Cefaclor [INN]

MeSH Heading

  • Cefaclor

Synonyms

  • (6R,7R)-7-((R)-2-Amino-2-phenylacetamido)-3-chloro-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
  • 3-Chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid
  • Ceclor
  • Ceclor CD
  • Cefaclor
  • Cefaclorum
  • Cefaclorum [INN-Latin]
  • Cephaclor
  • EINECS 258-909-5
  • Kefral
  • Lilly 99638
  • Panoral
  • Raniclor
  • S 6472
  • UNII-3Z6FS3IK0K

Systematic Names

  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((aminophenylacetyl)amino)-3-chloro-8-oxo-, (6R-(6-alpha,7-beta(R*)))-
  • Cefaclor

Registry Numbers

CAS Registry Number

  • 53994-73-3

FDA UNII

  • 3Z6FS3IK0K

System Generated Number

  • 0053994733

Structure Descriptors

InChI

1S/C15H14ClN3O4S/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23)/t9-,10-,14-/m1/s1

InChIKey

QYIYFLOTGYLRGG-GPCCPHFNSA-N

Smiles

N12[C@@H]([C@@H](NC([C@@H](c3ccccc3)N)=O)C1=O)SCC(=C2C(O)=O)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 131mg/kg/7D-I (131mg/kg) MUSCULOSKELETAL: JOINTS

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Canadian Medical Association Journal. Vol. 126, Pg. 1032, 1982.
infant TDLo oral 525mg/kg/7D-I (525mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Canadian Medical Association Journal. Vol. 126, Pg. 1032, 1982.
mouse LD50 intraperitoneal 1227mg/kg (1227mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Chemotherapy Vol. 27(Suppl,
mouse LD50 oral > 20gm/kg (20000mg/kg)   Chemotherapy Vol. 27(Suppl,
mouse LD50 oral > 20gm/kg (20000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: ATAXIA
Chemotherapy Vol. 27(Suppl,
mouse LD50 subcutaneous 4180mg/kg (4180mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Chemotherapy Vol. 27(Suppl,
rat LD50 intraperitoneal 1259mg/kg (1259mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Chemotherapy Vol. 27(Suppl,
rat LD50 oral > 20gm/kg (20000mg/kg)   Chemotherapy Vol. 27(Suppl,
rat LD50 oral > 20gm/kg (20000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: ATAXIA
Chemotherapy Vol. 27(Suppl,
rat LD50 subcutaneous 4838mg/kg (4838mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Chemotherapy Vol. 27(Suppl,

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 0.350 (none)   EST
Water Solubility 1.00E+04 mg/L   EXP
Atmospheric OH Rate Constant 1.35E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.