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Substance Name: Cefaclor [INN]
RN: 53994-73-3
UNII: 3Z6FS3IK0K
InChIKey: QYIYFLOTGYLRGG-GPCCPHFNSA-N
Note
- Semisynthetic, broad-spectrum antibiotic derivative of CEPHALEXIN.
Molecular Formula
- C15-H14-Cl-N3-O4-S
Molecular Weight
- 367.8116
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Bacterial Agents
- Anti-Infective Agents
- Drug / Therapeutic Agent
- Human Data
- Reproductive Effect
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Names and Synonyms
Results Name
- Cefaclor [INN]
Name of Substance
- Cefaclor anhydrous
- Cefaclor [INN]
MeSH Heading
- Cefaclor
Synonyms
- (6R,7R)-7-((R)-2-Amino-2-phenylacetamido)-3-chloro-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
- 3-Chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid
- Ceclor
- Ceclor CD
- Cefaclor
- Cefaclorum
- Cefaclorum [INN-Latin]
- Cephaclor
- EINECS 258-909-5
- Kefral
- Lilly 99638
- Panoral
- Raniclor
- S 6472
- UNII-3Z6FS3IK0K
Systematic Names
- 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((aminophenylacetyl)amino)-3-chloro-8-oxo-, (6R-(6-alpha,7-beta(R*)))-
- Cefaclor
Registry Numbers
CAS Registry Number
- 53994-73-3
FDA UNII
- 3Z6FS3IK0K
System Generated Number
- 0053994733
Structure Descriptors
InChI
1S/C15H14ClN3O4S/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23)/t9-,10-,14-/m1/s1InChIKey
QYIYFLOTGYLRGG-GPCCPHFNSA-NSmiles
N12[C@@H]([C@@H](NC([C@@H](c3ccccc3)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| child | TDLo | oral | 131mg/kg/7D-I (131mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" MUSCULOSKELETAL: JOINTS | Canadian Medical Association Journal. Vol. 126, Pg. 1032, 1982. |
| infant | TDLo | oral | 525mg/kg/7D-I (525mg/kg) | Canadian Medical Association Journal. Vol. 126, Pg. 1032, 1982. | |
| infant | TDLo | oral | 525mg/kg/7D-I (525mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Canadian Medical Association Journal. Vol. 126, Pg. 1032, 1982. |
| mouse | LD50 | intraperitoneal | 1227mg/kg (1227mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Chemotherapy Vol. 27(Suppl, |
| mouse | LD50 | oral | > 20gm/kg (20000mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: ATAXIA | Chemotherapy Vol. 27(Suppl, |
| mouse | LD50 | subcutaneous | 4180mg/kg (4180mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Chemotherapy Vol. 27(Suppl, |
| rat | LD50 | intraperitoneal | 1259mg/kg (1259mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Chemotherapy Vol. 27(Suppl, |
| rat | LD50 | oral | > 20gm/kg (20000mg/kg) | Chemotherapy Vol. 27(Suppl, | |
| rat | LD50 | oral | > 20gm/kg (20000mg/kg) | BEHAVIORAL: ATAXIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Chemotherapy Vol. 27(Suppl, |
| rat | LD50 | subcutaneous | 4838mg/kg (4838mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Chemotherapy Vol. 27(Suppl, |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| log P (octanol-water) | 0.350 | (none) | EST | |
| Water Solubility | 1.00E+04 | mg/L | EXP | |
| Atmospheric OH Rate Constant | 1.35E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.