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Substance Name: Sodium salicylate [USP:JAN]
RN: 54-21-7
UNII: WIQ1H85SYP
InChIKey: ABBQHOQBGMUPJH-UHFFFAOYSA-M
Note
- A non-steroidal anti-inflammatory agent that is less effective than equal doses of ASPIRIN in relieving pain and reducing fever. However, individuals who are hypersensitive to ASPIRIN may tolerate sodium salicylate. In general, this salicylate produces the same adverse reactions as ASPIRIN, but there is less occult gastrointestinal bleeding. (From AMA Drug Evaluations Annual, 1992, p120).
Molecular Formula
- C7-H6-O3.Na
Molecular Weight
- 160.1035
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Analgesic
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Cyclooxygenase Inhibitors
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Human Data
- Mutation Data
- Peripheral Nervous System Agents
- Reproductive Effect
- Sensory System Agents
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Names and Synonyms
Name of Substance
- 2-Hydroxybenzoic acid, monosodium salt
- Benzoic acid, 2-hydroxy-, monosodium salt
- Sodium salicylate
- Sodium salicylate [USP:JAN]
MeSH Heading
- Sodium salicylate
Synonyms
- 2-Hydroxybenzoic acid monosodium salt
- Alysine
- Aroall
- CCRIS 6715
- Clin
- Diuretin
- EC 200-198-0
- EINECS 200-198-0
- Enterosalicyl
- Enterosalil
- Entrosalyl
- Glutosalyl
- Idocyl novum
- Kerasalicyl
- Kerosal
- Magsalyl
- Monosodium 2-hydroxybenzoate
- Monosodium salicylate
- Nadisal
- Natrium salicylat
- Natrium salicylat [German]
- Natrum salicylicum
- Neo-salicyl
- NSC 202167
- o-Hydroxybenzoic acid monosodium salt
- o-Hydroxybenzoic acid, sodium salt
- Parbocyl-rev
- Salicylic acid, sodium salt
- Salisod
- Salsonin
- Sodium 2-hydroxybenzoate
- Sodium o-hydroxybenzoate
- Sodium salicylate
- UNII-WIQ1H85SYP
Systematic Names
- Benzoic acid, 2-hydroxy-, monosodium salt
- Benzoic acid, 2-hydroxy-, sodium salt (1:1)
- Salicylic acid, monosodium salt
- Sodium salicylate
Superlist Name
- Sodium salicylate
Mixture Names
- Corilin
- Cystex
- Pabalate
- Tinnitus
Registry Numbers
CAS Registry Number
- 54-21-7
FDA UNII
- WIQ1H85SYP
Other Registry Numbers
- 18495-69-7
- 94413-51-1
System Generated Number
- 0000054217
Molecular Formulas
Molecular Formula
- C7-H6-O3.Na
Molecular Formula Fragments
- C7-H6-O3
- COMPONENT
- Na
Structure Descriptors
InChI
InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1InChIKey
ABBQHOQBGMUPJH-UHFFFAOYSA-MSmiles
[Na+].Oc1ccccc1C(=O)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| child | TDLo | multiple routes | 2970mg/kg/13D (2970mg/kg) | BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: NAUSEA OR VOMITING | American Journal of Diseases of Children. Vol. 69, Pg. 37, 1945. |
| dog | LD50 | intravenous | 562mg/kg (562mg/kg) | BEHAVIORAL: ANALGESIA | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964. |
| dog | LDLo | intraperitoneal | 990mg/kg (990mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935. | |
| dog | LDLo | oral | 450mg/kg (450mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935. | |
| dog | LDLo | subcutaneous | 200mg/kg (200mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895. |
| frog | LDLo | subcutaneous | 250mg/kg (250mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935. | |
| guinea pig | LDLo | intraperitoneal | 900mg/kg (900mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935. | |
| guinea pig | LDLo | subcutaneous | 800mg/kg (800mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: EXCITEMENT CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) | Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895. |
| human | LDLo | oral | 700mg/kg (700mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | New England Journal of Medicine. Vol. 232, Pg. 617, 1945. |
| mouse | LD50 | intramuscular | 760mg/kg (760mg/kg) | Acta Paediatrica Scandinavica. Vol. 59, Pg. 517, 1970. | |
| mouse | LD50 | intraperitoneal | 500mg/kg (500mg/kg) | Strahlentherapie. Vol. 127, Pg. 245, 1965. | |
| mouse | LD50 | intravenous | 500mg/kg (500mg/kg) | British Patent Document. Vol. #1009195, | |
| mouse | LD50 | oral | 540mg/kg (540mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955. | |
| mouse | LD50 | subcutaneous | 550mg/kg (550mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 25, 1958. | |
| rabbit | LD50 | intravenous | 415mg/kg (415mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979. | |
| rabbit | LD50 | oral | 1700mg/kg (1700mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 89, Pg. 205, 1947. | |
| rat | LD50 | intraperitoneal | 542mg/kg (542mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979. | |
| rat | LD50 | oral | 930mg/kg (930mg/kg) | BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. Vol. 36(1-4), Pg. 10, 1989. |
| women | TDLo | unreported | 1400mg/kg (1400mg/kg) | SKIN AND APPENDAGES (SKIN): SWEATING: OTHER LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: TOXIC PSYCHOSIS | JAMA, Journal of the American Medical Association. Vol. 126, Pg. 806, 1944. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 213 dec | deg C | EXP | |
| log P (octanol-water) | -1.43E+00 | (none) | EXP | |
| Water Solubility | 1.25E+05 | mg/L | 25 | EXP |
| Vapor Pressure | 3.68E-11 | mm Hg | 25 | EST |
| Atmospheric OH Rate Constant | 3.05E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.