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Substance Name: Sodium salicylate [USP:JAN]
RN: 54-21-7
UNII: WIQ1H85SYP
InChIKey: ABBQHOQBGMUPJH-UHFFFAOYSA-M

Note

  • A non-steroidal anti-inflammatory agent that is less effective than equal doses of ASPIRIN in relieving pain and reducing fever. However, individuals who are hypersensitive to ASPIRIN may tolerate sodium salicylate. In general, this salicylate produces the same adverse reactions as ASPIRIN, but there is less occult gastrointestinal bleeding. (From AMA Drug Evaluations Annual, 1992, p120)

Molecular Formula

  • C7-H6-O3.Na

Molecular Weight

  • 160.1035
 

Classification Codes

  • Analgesic
  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Cyclooxygenase Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Human Data
  • Mutation Data
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • 2-Hydroxybenzoic acid, monosodium salt
  • Benzoic acid, 2-hydroxy-, monosodium salt
  • Sodium salicylate
  • Sodium salicylate [USP:JAN]

MeSH Heading

  • Sodium salicylate

Synonyms

  • 2-Hydroxybenzoic acid monosodium salt
  • Alysine
  • Aroall
  • CCRIS 6715
  • Clin
  • Diuretin
  • EC 200-198-0
  • EINECS 200-198-0
  • Enterosalicyl
  • Enterosalil
  • Entrosalyl
  • Glutosalyl
  • Idocyl novum
  • Kerasalicyl
  • Kerosal
  • Magsalyl
  • Monosodium 2-hydroxybenzoate
  • Monosodium salicylate
  • Nadisal
  • Natrium salicylat
  • Natrium salicylat [German]
  • Natrum salicylicum
  • Neo-salicyl
  • NSC 202167
  • o-Hydroxybenzoic acid monosodium salt
  • o-Hydroxybenzoic acid, sodium salt
  • Parbocyl-rev
  • Salicylic acid, sodium salt
  • Salisod
  • Salsonin
  • Sodium 2-hydroxybenzoate
  • Sodium o-hydroxybenzoate
  • Sodium salicylate
  • UNII-WIQ1H85SYP

Systematic Names

  • Benzoic acid, 2-hydroxy-, monosodium salt
  • Benzoic acid, 2-hydroxy-, sodium salt (1:1)
  • Salicylic acid, monosodium salt
  • Sodium salicylate

Superlist Name

  • Sodium salicylate

Mixture Names

  • Corilin
  • Cystex
  • Pabalate
  • Tinnitus

Registry Numbers

CAS Registry Number

  • 54-21-7

FDA UNII

  • WIQ1H85SYP

Other Registry Numbers

  • 18495-69-7
  • 94413-51-1

System Generated Number

  • 0000054217

Molecular Formulas

Molecular Formula

  • C7-H6-O3.Na

Molecular Formula Fragments

  • C7-H6-O3
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1

InChIKey

ABBQHOQBGMUPJH-UHFFFAOYSA-M

Smiles

c1(c(cccc1)O)C(=O)[O-].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo multiple routes 2970mg/kg/13D (2970mg/kg) BEHAVIORAL: EXCITEMENT

GASTROINTESTINAL: NAUSEA OR VOMITING
American Journal of Diseases of Children. Vol. 69, Pg. 37, 1945.
dog LD50 intravenous 562mg/kg (562mg/kg) BEHAVIORAL: ANALGESIA Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964.
dog LDLo intraperitoneal 990mg/kg (990mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.
dog LDLo oral 450mg/kg (450mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.
dog LDLo subcutaneous 200mg/kg (200mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895.
frog LDLo subcutaneous 250mg/kg (250mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.
guinea pig LDLo intraperitoneal 900mg/kg (900mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.
guinea pig LDLo subcutaneous 800mg/kg (800mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: EXCITEMENT

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895.
human LDLo oral 700mg/kg (700mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
New England Journal of Medicine. Vol. 232, Pg. 617, 1945.
mouse LD50 intramuscular 760mg/kg (760mg/kg)   Acta Paediatrica Scandinavica. Vol. 59, Pg. 517, 1970.
mouse LD50 intraperitoneal 500mg/kg (500mg/kg)   Strahlentherapie. Vol. 127, Pg. 245, 1965.
mouse LD50 intravenous 500mg/kg (500mg/kg)   British Patent Document. Vol. #1009195,
mouse LD50 oral 540mg/kg (540mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955.
mouse LD50 subcutaneous 550mg/kg (550mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 25, 1958.
rabbit LD50 intravenous 415mg/kg (415mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979.
rabbit LD50 oral 1700mg/kg (1700mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 89, Pg. 205, 1947.
rat LD50 intraperitoneal 542mg/kg (542mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979.
rat LD50 oral 930mg/kg (930mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. Vol. 36(1-4), Pg. 10, 1989.
women TDLo unreported 1400mg/kg (1400mg/kg) SKIN AND APPENDAGES (SKIN): SWEATING: OTHER

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: TOXIC PSYCHOSIS
JAMA, Journal of the American Medical Association. Vol. 126, Pg. 806, 1944.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 213 dec deg C   EXP
log P (octanol-water) -1.43E+00 (none)   EXP
Water Solubility 1.25E+05 mg/L 25 EXP
Vapor Pressure 3.68E-11 mm Hg 25 EST
Atmospheric OH Rate Constant 3.05E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.