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Substance Name: Furosemide [USAN:USP:INN:BAN:JAN]
RN: 54-31-9
UNII: 7LXU5N7ZO5
InChIKey: ZZUFCTLCJUWOSV-UHFFFAOYSA-N
Note
- A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
Molecular Formula
- C12-H11-Cl-N2-O5-S
Molecular Weight
- 330.7469
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Diuretic
- Diuretics
- Drug / Therapeutic Agent
- Human Data
- Membrane Transport Modulators
- Mutation Data
- Natriuretic Agents
- Reproductive Effect
- Sodium Potassium Chloride Symporter Inhibitors
- Tumor Data
Superlist Classification Code
- Overall Carcinogenic Evaluation: Group 3
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NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
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Names and Synonyms
Name of Substance
- Furosemide
- Furosemide [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Furosemide
Synonyms
- 2-Furfurylamino-4-chloro-5-sulfamoylbenzoic acid
- 4-Chloro-5-sulfamoyl-N-furfuryl-anthranilic acid
- 4-Chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid
- 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid
- 5-(Aminosulfonyl)-4-chloro-2-((2-furanylmethyl)amino)benzoic acid
- 5-18-09-00555 (Beilstein Handbook Reference)
- Aisemide
- Aldalix
- Aldic
- Aluzine
- Anfuramaide
- Anthranilic acid, 4-chloro-N-furfuryl-5-sulfamoyl-
- Apo-Frusemide
- Apo-Furosemide
- Aquarid
- Aquasin
- Arasemide
- Benzoic acid, 5-(aminosulfonyl)-4-chloro-2-((2-furanylmethyl)amino)-
- Beronald
- Bioretic
- BRN 0840915
- CCRIS 1951
- Cetasix
- Chlor-N-(2-furylmethyl)-5-sulfamylanthranilsaeure
- Chlor-N-(2-furylmethyl)-5-sulfamylanthranilsaeure [German]
- Depix
- Desal
- Desdemin
- Dirine
- Disal
- Discoid
- Disemide
- Diural
- Diurapid
- Diurin
- Diurolasa
- Diusemide
- Diusil
- Diuzol
- Dranex
- Dryptal
- Durafurid
- Edemid
- Edenol
- EINECS 200-203-6
- Eliur
- Endural
- Errolon
- Eutensin
- Farsix
- Fluidrol
- Fluss
- Franyl
- Frumex
- Frumide
- Frusedan
- Frusema
- Frusemid
- Frusemide
- Frusemin
- Frusenex
- Frusetic
- Frusid
- Fulsix
- Fuluvamide
- Fuluvamine
- Furanthril
- Furanthryl
- Furantril
- Furanturil
- Furesis
- Furetic
- Furex
- Furfan
- Furix
- Furmid
- Furo-Basan
- Furo-Puren
- Furobeta
- Furocot
- Furodiurol
- Furodrix
- Furomen
- Furomex
- Furomide M.D.
- Furorese
- Furosan
- Furose
- Furosedon
- Furosemid
- Furosemida
- Furosemida [INN-Spanish]
- Furosemide
- Furosemide mita
- Furosemide oral
- Furosemidu
- Furosemidu [Polish]
- Furosemidum
- Furosemidum [INN-Latin]
- Furosemix
- Furoside
- Furosifar
- Furosix
- Furoter
- Furovite
- Fursemid
- Fursemida
- Fursemide
- Fursol
- Fusid
- Golan
- Hissuflux
- HSDB 3086
- Hydrex
- Hydro
- Hydro-rapid
- Hydroled
- Impugan
- Jenafusid
- Katlex
- Kofuzon
- Kolkin
- Kutrix
- Lasemid
- Lasex
- Lasiletten
- Lasilix
- Lasix
- Lasix Retard
- Laxur
- Lazix
- LB 502
- LB-502
- less Diur
- Liside
- Logirene
- Lowpston
- Lowpstron
- Luscek
- Macasirool
- Marsemide
- Mirfat
- Mita
- Moilarorin
- Nadis
- NCI-C55936
- Nelsix
- Neo-renal
- Nephron
- Nicorol
- Novosemide
- NSC 269420
- Odemase
- Odemex
- Oedemex
- Osyrol
- Polysquall A
- Prefemin
- Profemin
- Promedes
- Promide
- Protargen
- Puresis
- Radisemide
- Radonna
- Radouna
- Retep
- Rosemide
- Rosis
- Rusyde
- Salinex
- Salix
- Salurex
- Salurid
- Seguril
- Selectofur
- Sigasalur
- Spirofur
- Synephron
- Transit
- Trofurit
- UNII-7LXU5N7ZO5
- Uremide
- Uresix
- Urex
- Urex-M
- Urian
- Uridon
- Uritol
- Urosemide
- Vesix
- Yidoli
- Zafimida
Systematic Names
- Anthranilic acid, 4-chloro-N-furfuryl-5-sulfamoyl-
- Benzoic acid, 5-(aminosulfonyl)-4-chloro-2-((2-furanylmethyl)amino)-
- Furosemide
Superlist Name
- Furosemide
Mixture Name
- Frumil
Registry Numbers
CAS Registry Number
- 54-31-9
FDA UNII
- 7LXU5N7ZO5
Related Registry Number
- 41733-55-5 (mono-hydrochloride salt)
System Generated Number
- 0000054319
Structure Descriptors
InChI
1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)InChIKey
ZZUFCTLCJUWOSV-UHFFFAOYSA-NSmiles
c1(c(cc(c(c1)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intravenous | > 400mg/kg (400mg/kg) | Drugs in Japan Vol. 6, Pg. 725, 1982. | |
| dog | LD50 | oral | 2gm/kg (2000mg/kg) | Drugs in Japan Vol. 6, Pg. 725, 1982. | |
| human | TDLo | intravenous | 1300ug/kg (1.3mg/kg) | VASCULAR: REGIONAL OR GENERAL ARTERIOLAR CONSTRICTION CARDIAC: OTHER CHANGES | Annals of Internal Medicine. Vol. 103, Pg. 1, 1985. |
| infant | TDLo | intravenous | 1mg/kg/4H-I (1mg/kg) | Archives of Disease in Childhood. Vol. 59, Pg. 907, 1984. | |
| man | TDLo | intravenous | 29mg/kg (29mg/kg) | KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR | New England Journal of Medicine. Vol. 282, Pg. 1413, 1970. |
| mouse | LD50 | intravenous | 308mg/kg (308mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 44, 1964. | |
| mouse | LD50 | oral | 2gm/kg (2000mg/kg) | European Patent Application. Vol. #0008367, | |
| mouse | LD50 | unreported | 900mg/kg (900mg/kg) | European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 15, Pg. 386, 1980. | |
| rabbit | LD50 | intravenous | 400mg/kg (400mg/kg) | Drugs in Japan Vol. 6, Pg. 725, 1982. | |
| rabbit | LD50 | oral | 800mg/kg (800mg/kg) | Drugs in Japan Vol. 6, Pg. 725, 1982. | |
| rat | LD50 | intraperitoneal | 800mg/kg (800mg/kg) | Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 42, Pg. 199, 1985. | |
| rat | LD50 | intravenous | 800mg/kg (800mg/kg) | Drugs in Japan Vol. 6, Pg. 725, 1982. | |
| rat | LD50 | oral | 2600mg/kg (2600mg/kg) | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. | |
| rat | LD50 | subcutaneous | 4600mg/kg (4600mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967. | |
| women | TDLo | intravenous | 2500ug/kg/2M- (2.5mg/kg) | CARDIAC: PULSE RATE | Intensive Care Medicine. Vol. 12, Pg. 54, 1986. |
| women | TDLo | oral | 6250ug/kg (6.25mg/kg) | Journal of Toxicology, Clinical Toxicology. Vol. 31, Pg. 341, 1993. | |
| women | TDLo | oral | 6250ug/kg (6.25mg/kg) | Journal of Toxicology, Clinical Toxicology. Vol. 31, Pg. 341, 1993. | |
| women | TDLo | oral | 6250ug/kg (6.25mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS | Journal of Toxicology, Clinical Toxicology. Vol. 31, Pg. 341, 1993. |
| women | TDLo | oral | 120mg/kg/21W- (120mg/kg) | KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS | Journal of the Royal Society of Medicine. Vol. 79, Pg. 239, 1986. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 295 | deg C | EXP | |
| log P (octanol-water) | 2.03 | (none) | EXP | |
| Water Solubility | 73.1 | mg/L | 30 | EXP |
| Vapor Pressure | 3.23E-10 | mm Hg | 25 | EST |
| Henry's Law Constant | 3.94E-16 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 1.12E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.