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Substance Name: Moxisylyte [INN:BAN:DCF]
RN: 54-32-0
UNII: PW8QYA7KI0
InChIKey: VRYMTAVOXVTQEF-UHFFFAOYSA-N

Note

  • An alpha-adrenergic blocking agent that is used in Raynaud's disease. It is also used locally in the eye to reverse the mydriasis caused by phenylephrine and other sympathomimetic agents. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1312)

Molecular Formula

  • C16-H25-N-O3

Molecular Weight

  • 279.378
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic alpha-Antagonists
  • Adrenergic Antagonists
  • Autonomic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Miotics
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Sympatholytics
  • Vasodilator Agents
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Names and Synonyms

Name of Substance

  • Moxisylyte
  • Moxisylyte [INN:BAN:DCF]

MeSH Heading

  • Moxisylyte

Synonyms

  • (2-(4-Acetoxy-2-isopropyl-5-methylphenoxy)ethyl)dimethylamine
  • 4-(2-(Dimethylamino)ethoxy)-2-methyl-5-(1-methylethyl)phenol acetate (ester)
  • Arlytene
  • Carvacrol, 5-(2-(dimethylamino)ethoxy)-, acetate (ester)
  • EINECS 200-204-1
  • Moxilite
  • Moxisilita
  • Moxisilita [INN-Spanish]
  • Moxisylyt
  • Moxisylyte
  • Moxisylytum
  • Moxisylytum [INN-Latin]
  • Sympal
  • Thymoxamine
  • Timoxamina
  • UNII-PW8QYA7KI0
  • Vasoklin

Systematic Names

  • (2-(4-Acetoxy-2-isopropyl-5-methylphenoxy)ethyl)dimethylamine
  • Moxisylyte
  • Phenol, 4-(2-(dimethylamino)ethoxy)-2-methyl-5-(1-methylethyl)-, acetate (ester)

Registry Numbers

CAS Registry Number

  • 54-32-0

FDA UNII

  • PW8QYA7KI0

System Generated Number

  • 0000054320

Structure Descriptors

InChI

1S/C16H25NO3/c1-11(2)14-10-15(20-13(4)18)12(3)9-16(14)19-8-7-17(5)6/h9-11H,7-8H2,1-6H3

InChIKey

VRYMTAVOXVTQEF-UHFFFAOYSA-N

Smiles

c1(c(cc(C)c(c1)OC(C)=O)OCCN(C)C)C(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 73mg/kg (73mg/kg)   European Patent Application. Vol. #0062596,
mouse LD50 oral 225mg/kg (225mg/kg)   European Patent Application. Vol. #0062596,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 144.5 deg C   EXP
pKa Dissociation Constant 8.72 (none)   EXP
log P (octanol-water) 3.17 (none)   EXP
Water Solubility 323 mg/L 25 EST
Vapor Pressure 2.78E-05 mm Hg 25 EST
Henry's Law Constant 5.42E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.58E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.