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Substance Name: Pyridoxal phosphate
RN: 54-47-7
UNII: F06SGE49M6
InChIKey: NGVDGCNFYWLIFO-UHFFFAOYSA-N

Note

  • This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).

Molecular Formula

  • C8-H10-N-O6-P

Molecular Weight

  • 247.142
 

Classification Codes

  • Drug / Therapeutic Agent
  • Growth Substances
  • Micronutrients
  • Mutation Data
  • Vitamin B Complex
  • Vitamins
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Names and Synonyms

Results Name

  • Pyridoxal phosphate

Name of Substance

  • 3-Hydroxy-2-methyl-5-((phosphonooxy)methyl)-4-pyridinecarboxaldehyde
  • 4-Pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-((phosphonooxy)methyl)-
  • Pyridoxal 5-phosphate
  • Pyridoxal calcium phosphate [JAN]
  • Pyridoxal phosphate

MeSH Heading

  • Pyridoxal phosphate

Synonyms

  • 2-Methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine-5-calcium phosphate trihydrate
  • 4-Pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-((phosphonooxy)methyl)-
  • Apolon B(sub 6)
  • Apolon B6
  • Biosechs
  • Codecarboxylase
  • Coenzyme B6
  • EINECS 200-208-3
  • Hairoxal
  • Hexermin P
  • HI-Pyridoxin
  • Hiadelon
  • Himitan
  • NSC 82388
  • Pal-P
  • Phosphopyridoxal
  • Phosphopyridoxal coenzyme
  • Phosphoridoxal coenzyme
  • Pidopidon
  • Piodel
  • PLP
  • Pydoxal
  • Pyridoxal 5-phosphate
  • Pyridoxal calcium phosphate
  • Pyridoxal monophosphate
  • Pyridoxal P
  • Pyridoxal phosphate
  • Pyridoxal-5'-phosphate
  • Pyridoxaldehyde phosphate
  • Pyridoxyl phosphate
  • Pyromijin
  • Sechvitan
  • UNII-F06SGE49M6
  • Vitahexin P
  • Vitazechs

Systematic Names

  • 2-Methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine-5-calcium phosphate
  • 4-Pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-((phosphonooxy)methyl)-
  • Pyridoxal 5'-(dihydrogen phosphate)

Registry Numbers

CAS Registry Number

  • 54-47-7

FDA UNII

  • F06SGE49M6

Other Registry Numbers

  • 1071665-72-9
  • 52064-48-9
  • 52441-27-7

System Generated Number

  • 0000054477

Structure Descriptors

InChI

InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)

InChIKey

NGVDGCNFYWLIFO-UHFFFAOYSA-N

Smiles

Cc1ncc(COP(=O)(O)O)c(C=O)c1O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LD50 oral > 3gm/kg (3000mg/kg)   British Patent Document. Vol. #1172800,
mammal (species unspecified) LD50 subcutaneous 550mg/kg (550mg/kg)   British Patent Document. Vol. #1172800,
mouse LD50 intramuscular 1150mg/kg (1150mg/kg) BEHAVIORAL: ANTIPSYCHOTIC Pharmaceutical Chemistry Journal Vol. 15, Pg. 303, 1981.
mouse LD50 intravenous 530mg/kg (530mg/kg)   Drugs in Japan Vol. 6, Pg. 643, 1982.
mouse LD50 oral 4640mg/kg (4640mg/kg)   Drugs in Japan Vol. 6, Pg. 643, 1982.
mouse LD50 subcutaneous 870mg/kg (870mg/kg)   Drugs in Japan Vol. 6, Pg. 643, 1982.
rat LD50 oral 5900mg/kg (5900mg/kg)   Drugs in Japan Vol. 6, Pg. 643, 1982.
rat LD50 subcutaneous 850mg/kg (850mg/kg)   Drugs in Japan Vol. 6, Pg. 643, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 255 deg C   EXP
log P (octanol-water) 0.370 (none)   EST
Water Solubility 1.19E+04 mg/L 25 EST
Vapor Pressure 3.28E-10 mm Hg 25 EST
Henry's Law Constant 9.26E-20 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 4.29E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.