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Substance Name: Dimethylphenylpiperazinium Iodide
RN: 54-77-3
UNII: X95H7DRX99
InChIKey: XFZJGFIKQCCLGK-UHFFFAOYSA-M

Note

  • A selective nicotinic cholinergic agonist used as a research tool. DMPP activates nicotinic receptors in autonomic ganglia but has little effect at the neuromuscular junction.

Molecular Formula

  • C12-H19-N2.I

Molecular Weight

  • 318.196
 

Classification Codes

  • Autonomic Agents
  • Cholinergic Agents
  • Cholinergic Agonists
  • Drug / Therapeutic Agent
  • Ganglionic Stimulants
  • Neurotransmitter Agents
  • Nicotinic Agonists
  • Peripheral Nervous System Agents
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Names and Synonyms

Results Name

  • Dimethylphenylpiperazinium iodide

Name of Substance

  • DMPP

MeSH Heading

  • Dimethylphenylpiperazinium iodide

Synonyms

  • 1,1-Dimethyl-4-phenylpiperazine iodide
  • 1,1-Dimethyl-4-phenylpiperazinium iodide
  • Dimethyl-4-phenylpiperazium iodide
  • Dimethylphenylpiperazinium iodide
  • DMPP
  • DMPP iodide
  • EINECS 200-213-0
  • N,N-Dimethyl-N'-phenylpiperazinium iodide
  • NSC 89754
  • UNII-X95H7DRX99

Systematic Names

  • 1,1-Dimethyl-4-phenylpiperazinium iodide
  • Piperazinium, 1,1-dimethyl-4-phenyl-, iodide

Registry Numbers

CAS Registry Number

  • 54-77-3

FDA UNII

  • X95H7DRX99

System Generated Number

  • 0000054773

Molecular Formulas

Molecular Formula

  • C12-H19-N2.I

Molecular Formula Fragments

  • C12-H19-N2
  • COMPONENT
  • I

Structure Descriptors

InChI

1S/C12H19N2.HI/c1-14(2)10-8-13(9-11-14)12-6-4-3-5-7-12;/h3-7H,8-11H2,1-2H3;1H/q+1;/p-1

InChIKey

XFZJGFIKQCCLGK-UHFFFAOYSA-M

Smiles

N1(c2ccccc2)CC[N+](C)(C)CC1.[IH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 28mg/kg (28mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE WEAKNESS
Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 330, 1951.
mouse LD50 intraperitoneal 18500ug/kg (18.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives Internationales de Pharmacodynamie et de Therapie. Vol. 97, Pg. 186, 1954.
mouse LD50 intravenous 1600ug/kg (1.6mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
European Journal of Pharmacology. Vol. 11, Pg. 75, 1970.
mouse LD50 subcutaneous 1030mg/kg (1030mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 61(2), Pg. 39S, 1965.
rabbit LD50 intravenous 1mg/kg (1mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 330, 1951.