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Substance Name: Pronetalol [INN:BAN]
RN: 54-80-8
UNII: XBP4RT1IMQ
InChIKey: HRSANNODOVBCST-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
  • Tumor Data

Molecular Formula

  • C15-H19-N-O

Molecular Weight

  • 229.3211
 
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Names and Synonyms

Name of Substance

  • Pronetalol [INN:BAN]
  • Pronethalol

Synonyms

  • (+-)-Pronethalol
  • (2-Naphthyl)-1-isopropylaminoethanol
  • 2-Isopropylamino-1-(naphth-2-yl)ethanol
  • Alderlin
  • AY 6204 [as hydrochloride]
  • CCRIS 9216
  • Compound 38174
  • ICI 38174 [as hydrochloride]
  • Inetol
  • Naphthylisoproterenol
  • Neathalide
  • NETH
  • Nethalide
  • Pronetalol
  • Pronetalolo
  • Pronetalolo [DCIT]
  • Pronetalolum
  • Pronetalolum [INN-Latin]
  • Pronethalol
  • UNII-XBP4RT1IMQ

Systematic Names

  • 2-Isopropylamino-1-(naphth-2-yl)ethanol
  • 2-Naphthalenemethanol, alpha-(((1-methylethyl)amino)methyl)-
  • 2-Naphthalenemethanol, alpha-((isopropylamino)methyl)-

Registry Numbers

CAS Registry Number

  • 54-80-8

FDA UNII

  • XBP4RT1IMQ

System Generated Number

  • 0000054808

Structure Descriptors

InChI

1S/C15H19NO/c1-11(2)16-10-15(17)14-8-7-12-5-3-4-6-13(12)9-14/h3-9,11,15-17H,10H2,1-2H3

InChIKey

HRSANNODOVBCST-UHFFFAOYSA-N

Smiles

CC(C)NCC(c1ccc2ccccc2c1)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 124mg/kg (124mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 149, Pg. 161, 1965.
mouse LD50 intravenous 28800ug/kg (28.8mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 794, 1978.
mouse LD50 oral 337mg/kg (337mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 149, Pg. 161, 1965.
rat LD50 intravenous 45mg/kg (45mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Lancet. Vol. 2, Pg. 311, 1962.
rat LD50 oral 900mg/kg (900mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Lancet. Vol. 2, Pg. 311, 1962.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 108 deg C   EXP
pKa Dissociation Constant 9.42 (none)   EXP
log P (octanol-water) 3 (none)   EXP
Water Solubility 857 mg/L 25 EST
Vapor Pressure 3.08E-07 mm Hg 25 EST
Henry's Law Constant 1.12E-11 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.52E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.