Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Amifampridine [USAN:INN:BAN]
RN: 54-96-6
UNII: RU4S6E2G0J
InChIKey: OYTKINVCDFNREN-UHFFFAOYSA-N

Note

  • Potassium channel blocker in membranes.

Molecular Formula

  • C5-H7-N3

Molecular Weight

  • 109.131
 

Classification Codes

  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Membrane Transport Modulators
  • Potassium Channel Blockers
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • 3,4-Diaminopyridine
  • Amifampridine [USAN:INN:BAN]

Synonyms

  • 3,4-DAP
  • 3,4-Diaminopyridine
  • 3,4-Pyridinediamine
  • 4,5-Diaminopyridine
  • 5-22-11-00266 (Beilstein Handbook Reference)
  • Amifampridine
  • BRN 0110232
  • Diamino-3,4 pyridine
  • EINECS 200-220-9
  • Firdapse
  • NSC 521760
  • SC10
  • UNII-RU4S6E2G0J
  • Zenas

Systematic Names

  • 3,4-Diaminopyridine
  • 3,4-Pyridinediamine
  • Pyridine, 3,4-diamino-

Registry Numbers

CAS Registry Number

  • 54-96-6

FDA UNII

  • RU4S6E2G0J

System Generated Number

  • 0000054966

Structure Descriptors

InChI

1S/C5H7N3/c6-4-1-2-8-3-5(4)7/h1-3H,7H2,(H2,6,8)

InChIKey

OYTKINVCDFNREN-UHFFFAOYSA-N

Smiles

c1(c(cncc1)N)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 75mg/kg (75mg/kg)   Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
mouse LD50 intraperitoneal 20mg/kg (20mg/kg)   Journal of Medicinal Chemistry. Vol. 8, Pg. 296, 1965.
mouse LD50 intravenous 13mg/kg (13mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Annales Pharmaceutiques Francaises. Vol. 26, Pg. 345, 1968.
mouse LD50 subcutaneous 35mg/kg (35mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 150, Pg. 413, 1964.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 220 deg C   EXP
log P (octanol-water) -1.030 (none)   EST
Atmospheric OH Rate Constant 3.35E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.