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Substance Name: 1,2-Dimethylhydrazine
RN: 540-73-8
UNII: IX068S9745
InChIKey: DIIIISSCIXVANO-UHFFFAOYSA-N

Note

  • A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.

Molecular Formula

  • C2-H8-N2

Molecular Weight

  • 60.0992
 

Classification Codes

Classification Codes

  • Alkylating Agents
  • Carcinogens
  • Mutagens
  • Mutation Data
  • Noxae
  • Reproductive Effect
  • Tumor Data

Superlist Classification Codes

  • Overall Carcinogenic Evaluation: Group 2A
  • Reportable Quantity (RQ) = 1 lb
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Names and Synonyms

Name of Substance

  • 1,2-Dimethylhydrazine

MeSH Heading

  • 1,2-Dimethylhydrazine

Synonyms

  • 1,2-Dimethyl-hydrazine
  • 1,2-Dimethylhydrazin
  • 1,2-Dimethylhydrazin [German]
  • 1,2-Dimethylhydrazine
  • 1,2-DMH
  • 4-04-00-03323 (Beilstein Handbook Reference)
  • BRN 1730826
  • CCRIS 259
  • DMH
  • HSDB 4039
  • Hydrazine, 1,2-dimethyl-
  • Hydrazomethane
  • N,N'-Dimethylhydrazine
  • RCRA waste number U099
  • SDMH
  • sym-Dimethylhydrazine
  • Symetryczna dwumetylohydrazyna
  • Symetryczna dwumetylohydrazyna [Polish]
  • Symmetrical-dimethylhydrazine
  • UNII-IX068S9745

Systematic Names

  • 1,2-Dimethylhydrazine
  • Hydrazine, 1,2-dimethyl-

Superlist Names

  • 1,2-Dimethylhydrazine
  • Dimethylhydrazine, symmetrical
  • Dimethylhydrazine, symmetrical [UN2382] [Poison]
  • Hydrazine, 1,2-dimethyl-
  • RCRA waste no. U099
  • UN2382

Registry Numbers

CAS Registry Number

  • 540-73-8

FDA UNII

  • IX068S9745

System Generated Number

  • 0000540738

Structure Descriptors

InChI

1S/C2H8N2/c1-3-4-2/h3-4H,1-2H3

InChIKey

DIIIISSCIXVANO-UHFFFAOYSA-N

Smiles

N(NC)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 100mg/kg (100mg/kg)   Medycyna Pracy. Industrial Medicine. Vol. 24, Pg. 71, 1973.
hamster LD50 intramuscular 95mg/kg (95mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1891, 1969.
mouse LD50 intraperitoneal 35mg/kg (35mg/kg)   Medycyna Pracy. Industrial Medicine. Vol. 24, Pg. 71, 1973.
mouse LD50 intravenous 29mg/kg (29mg/kg)   Medycyna Pracy. Industrial Medicine. Vol. 24, Pg. 71, 1973.
mouse LD50 oral 36mg/kg (36mg/kg)   Medycyna Pracy. Industrial Medicine. Vol. 24, Pg. 71, 1973.
mouse LD50 subcutaneous 24mg/kg (24mg/kg)   Toxicology Letters. Vol. 8, Pg. 87, 1981.
rat LCLo inhalation 280ppm/4H (280ppm) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
AMA Archives of Industrial Health. Vol. 12, Pg. 609, 1955.
rat LD50 intraperitoneal 163mg/kg (163mg/kg)   Medycyna Pracy. Industrial Medicine. Vol. 24, Pg. 71, 1973.
rat LD50 intravenous 176mg/kg (176mg/kg)   Medycyna Pracy. Industrial Medicine. Vol. 24, Pg. 71, 1973.
rat LD50 oral 100mg/kg (100mg/kg)   Naturwissenschaften. Vol. 54, Pg. 285, 1967.
rat LD50 subcutaneous 220mg/kg (220mg/kg)   Xenobiotica. Vol. 3, Pg. 271, 1973.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -9.00E+00 deg C   EXP
Boiling Point 81 deg C   EXP
log P (octanol-water) -0.540 (none)   EST
Water Solubility 1.00E+06 mg/L 25 EXP
Vapor Pressure 69.9 mm Hg 25 EXP
Henry's Law Constant 6.95E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.29E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.