Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Vinformide [INN]
RN: 54022-49-0
UNII: I4U9NZS9T5
InChIKey: GLDSBTCHEGZWCV-NVDFJPPOSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data

Molecular Formula

  • C46-H54-N4-O10

Molecular Weight

  • 822.9506
 
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Formyl-leurosine
  • Vinformide [INN]

Synonyms

  • 22-Oxoleurosine
  • 4'-Desoxy-3'alpha,4'alpha-epoxyvincristin
  • f-Leu
  • F-Leurosine
  • Formyl-leurosine
  • Leuroformine
  • N-Formylleurosine
  • NSC 269419
  • UNII-I4U9NZS9T5
  • Vinformida
  • Vinformida [INN-Spanish]
  • Vinformide
  • Vinformidum
  • Vinformidum [INN-Latin]

Systematic Names

  • Formyl-leurosine
  • N-Demethyl-N-formylleurosine
  • Vincaleukoblastine, 4'-deoxy-3',4'-epoxy-22-oxo-, (3'-alpha,4'-alpha)- (9CI)

Registry Numbers

CAS Registry Number

  • 54022-49-0

FDA UNII

  • I4U9NZS9T5

System Generated Number

  • 0054022490

Structure Descriptors

InChI

1S/C46H54N4O10/c1-7-42-15-11-17-49-19-16-44(37(42)49)30-20-31(34(56-4)21-33(30)50(25-51)38(44)46(55,41(54)58-6)39(42)59-26(3)52)45(40(53)57-5)22-27-23-48(24-43(8-2)36(27)60-43)18-14-29-28-12-9-10-13-32(28)47-35(29)45/h9-13,15,20-21,25,27,36-39,47,55H,7-8,14,16-19,22-24H2,1-6H3/t27-,36+,37-,38+,39+,42+,43-,44+,45-,46-/m0/s1

InChIKey

GLDSBTCHEGZWCV-NVDFJPPOSA-N

Smiles

CC[C@]12CN3CCc4c([nH]c5ccccc45)[C@@](C[C@@H](C3)[C@H]1O2)(C(=O)OC)c6cc7c(cc6OC)N(C=O)[C@H]8[C@](O)([C@H](OC(=O)C)[C@]9(CC)C=CCN%10CC[C@]78[C@H]9%10)C(=O)OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo intravenous 500ug/kg (0.5mg/kg)   Antibiotics and Chemotherapy Vol. 23, Pg. 50, 1978.
mouse LD50 intraperitoneal 28800ug/kg (28.8mg/kg)   United States Patent Document. Vol. #4279915,
mouse LD50 intravenous 32500ug/kg (32.5mg/kg)   United States Patent Document. Vol. #4279915,