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Substance Name: 19-Nortestosterone nitrosocarbamate
RN: 54025-36-4
InChIKey: KTQUNVRSLAGBSY-WLGSGIEKSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Hormone

Molecular Formula

  • C21-H29-Cl-N2-O4

Molecular Weight

  • 408.923
 
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Names and Synonyms

Name of Substance

  • 19-Nortestosterone nitrosocarbamate

Synonyms

  • (17-beta)-17-((((2-Chloroethyl)nitrosoamino)carbonyl)oxy)estr-4-en-3-one
  • 19-Nortestosterone-17/N-(2-chloroethyl)-N-nitrosocarbamate
  • LEO 1727
  • LS 1727
  • NSC 269719

Systematic Name

  • Estr-4-en-3-one, 17-((((2-chloroethyl)nitrosoamino)carbonyl)oxy)-, (17-beta)-

Registry Numbers

CAS Registry Number

  • 54025-36-4

System Generated Number

  • 0054025364

Structure Descriptors

InChI

1S/C21H29ClN2O4/c1-21-9-8-16-15-5-3-14(25)12-13(15)2-4-17(16)18(21)6-7-19(21)28-20(26)24(23-27)11-10-22/h12,15-19H,2-11H2,1H3/t15?,16?,17?,18?,19-,21?/m0/s1

InChIKey

KTQUNVRSLAGBSY-WLGSGIEKSA-N

Smiles

C1[C@@H]2[C@@H]3[C@@H]([C@@H]4C(=CC(=O)CC4)CC3)CC[C@@]2([C@H](OC(N(CCCl)N=O)=O)C1)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD10 oral 1630mg/kg (1630mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH Acta Pharmacologica et Toxicologica. Vol. 49, Pg. 290, 1981.
mouse LD50 intraperitoneal 98mg/kg (98mg/kg)   Acta Pharmacologica et Toxicologica. Vol. 49, Pg. 290, 1981.
mouse LD50 intraperitoneal 98mg/kg (98mg/kg) GASTROINTESTINAL: PERITONITIS Acta Pharmacologica et Toxicologica. Vol. 49, Pg. 290, 1981.
mouse LD50 intravenous 8mg/kg (8mg/kg) GASTROINTESTINAL: GASTRITIS

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Acta Pharmacologica et Toxicologica. Vol. 49, Pg. 290, 1981.
rat LD50 intraperitoneal 155mg/kg (155mg/kg) GASTROINTESTINAL: GASTRITIS Acta Pharmacologica et Toxicologica. Vol. 49, Pg. 290, 1981.
rat LD50 intravenous 4mg/kg (4mg/kg) GASTROINTESTINAL: GASTRITIS

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Acta Pharmacologica et Toxicologica. Vol. 49, Pg. 290, 1981.
rat LD50 oral 2190mg/kg (2190mg/kg) GASTROINTESTINAL: GASTRITIS Acta Pharmacologica et Toxicologica. Vol. 49, Pg. 290, 1981.